摘要
目的:探讨血清降钙素原(PCT)在早期评估细菌感染严重程度中的应用价值,并与C反应蛋白(CRP)、白细胞计数(WBC)及体温进行比较。方法:根据美国胸科医师学会和危重病医学会会议(ACCP/SCCM)标准及临床表现,将139例细菌感染患者分为局部感染组(A组)50例、脓毒血症组(B组)5l例、严重脓毒血症组(C组)21例及脓毒性休克组(D组)17例,选取同期住院但无感染的患者20例为对照组。入选患者入院治疗前抽血查PCT、CBP及WBC水平、记录体温,治疗5天后复查PCT水平。结果:PCT水平以D组最高,为(42.36±48.49)ng/mL,高于其余各感染组(P均<0.05)。C组PCT(4.66±2.46)ng/mL,高于B组的(1.08±0.68)ng/mL及A组的(0.09±0.05)ng/mL(P均<0.05)。各感染组PCT水平均高于对照组的(0.05±0.01)ng/mL(P均<0.05);各组CRP、WBC水平及体温比较差异均无统计学意义(P均>O.05)。治疗5天后所有感染组PCT较治疗前均下降,差异有统计学意义(P<0.01)。结论:PCT水平可以早期评估细菌感染的严重程度,有助于监测病情变化。
Objective：To explore the value of serum procalcitonin（PCT）for early evaluation of the severity in bacterial infection and compare it with C reactive protein（CRP）,white blood cell count（WBC）,and temperature to understand their strength and weaknesses.Methods： A total of 139 patients with bacterial infection administered in our hospital from July 2009 to June 2010 were divided into 4 groups,including local bacterial infection group（Group A,n=50）,sepsis group（Group B,n=51）,severe sepsis group（Group C,n=21）,and septic shock group（Group D,n=17） according to ACCP/SCCM consensus conference and the clinical manifestations.Twenty noninfectious patients during the same period were recruited as control（Group E,n=20）.PCT,CRP,WBC,and temperature were evaluated in all patients before treatment and PCT were measured again 5 days after treatment.Results： During the early period of bacterial infection,PCT was the highest in Group D（[42.36±48.49] ng/mL）,followed by（4.66±2.46）ng/mL in Group C,（1.08±0.68） ng/mL in Group B,and（0.09±0.05）ng/mL in Group A（P〈0.05）.PCT in the 4 infectious groups were all higher than that in Group E [（0.05±0.01）ng/mL,P〈0.05].No significant difference in CRP,WBC,and temperature was noted among all groups（P〈0.05）.After 5-day treatment,PCT decreased in the 4 infectious groups than that before treatment（P〈0.01）.Conclusion： The level of PCT can be used to evaluate the severity of bacterial infection at the early stage.This may be of help for monitoring the patient＇s condition.
出处
《浙江中西医结合杂志》
2012年第5期333-335,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
关键词
细菌感染
血清降钙素原
C反应蛋白
白细胞计数
体温
评估
bacterial infection procalcitonin C-reactive protein White blood cell count temperature evaluation
