摘要
目的回顾性分析轻微血糖升高对大陆地区孕妇不良妊娠结局的影响。方法符合以下入选标准:①年龄大于18岁;②单胎、头胎、胎龄符合孕周;③于孕24～32周行50 g GCT试验,1 h PG≥7.8 mmol/L者于1周内行75 g OGTT试验,且OGTT试验在正常范围内(FBG<5.1 mmol/L、1 h<10.0 mmol/L、2 h<8.5 mmol/L)。结果共有527例符合入选标准,根据血糖水平高低将FBG、1 h BG、2 h BG等各分为4个亚组,每个亚组相差一个标准差。随着FBG、1 hBG、2 h BG水平升高,大于胎龄儿、新生儿高胆红素血症的发生率也随着增加;而胎儿宫腔内感染、先兆子痫、1 minApgar评分低及转儿科监护治疗的发生率并未达到差异具有统计学意义的升高。结论对于轻微血糖升高的孕妇而言,大于胎龄儿、新生儿高胆红素血症的血糖阈值是4.6 mmol/L<FBG≤5.0 mmol/L、9.5 mmol/L<1 h BG≤9.9 mmol/L、8.0 mmol/L<2 h BG≤8.4 mmol/L,而需转新生儿监护治疗的血糖阈值是4.6 mmol/L<FBG≤5.0 mmol/L、9.5 mmol/L<1 h BG≤9.9 mmol/L。但这仍需更大规模的前瞻性研究加以证实。
Objective To analyze the effect of mild gestational heperglycemia on adverse pregnant outcome retrospectively.Methods The study subjects were selected based on age more than 18 years,first pregnancy,single fetus,gestational age matched with pregnant weeks,and the normal glucose value while receiving oral glucose tolerance test with the use of a 75 g dose of glucose between 24 and 32 weeks of gestation.Results 527 pregnant women were included in the study.The FBG,1 h BG and 2 h BG were subdivided into four subgroups.The incidence of weight above the 90th percentile and neonatal hyperbilirubinemia were elevated with increased glucose level.However,the prevalence of intrauterine infection,eclampsia and lower 1 min Apgar score were not significantly increased.Conclusion For pregnant women with mild hyperglycemia,the glucose thresholds for large for gestational age and neonatal hyperbilirubinemia was 4.6 mmol/LFBG≤5.0 mmol/L,9.5 mmol/L1 h BG≤ 9.9 mmol/L and 8.0 mmol/L2 h BG≤8.4 mmol/L,respectively,while the need for neonatal intensive care was 4.6 mmol/LFBG≤5.0 mmol/L and 9.5 mmol/L1 h BG≤9.9 mmol/L,respectively.However,large-scale prospective studies are needed.
出处
《热带医学杂志》
CAS
2012年第5期583-585,588,共4页
Journal of Tropical Medicine
基金
广东省科技计划项目(2009B11400036)
关键词
糖尿病
血糖
妊娠
妊娠结局
diabetes mellitus
glycemia
pregnancy
pregnancy outcome
