摘要
成熟哺乳动物中枢神经系统损伤后轴突的再生是极其有限的。中枢神经再生困难之一是其内在的髓鞘相关抑制因子(MAIs)的存在,Nogo-A蛋白、髓鞘相关糖蛋白、少突胶质细胞髓鞘糖蛋白是三个经典的MAIs。这三个分子由少突胶质细胞产生,并通过Nogo受体和配对免疫球蛋白样受体B共同的神经受体激活小GTP酶Ras同源基因家族成员(Rho),进而活化的RhoA激活Rho相关激酶抑制中枢神经系统轴突的再生。现就MAIs在中枢神经系统轴突再生中的作用予以综述,并探讨其可能的治疗措施以促进中枢神经轴突再生和功能恢复。
The regeneration of the rear axle axon of the central nervous system of mature mammals is extremely limited after damage.Central nerve regeneration is difficult because of its inherent myelin-associated inhibitors（MAIs）.Nogo-A protein,myelin-associated glycoprotein,oligodendrocytes myelin glycoprotein protein are three classical MAIs.The three molecules are all produced by oligodendrocytes,and through the Nogo receptors and pair immunoglobulin-like receptor B activate small GTP enzyme Ras homology gene family members（Rho）,and the activated RhoA activates Rho related kinase,thus inhibites the neurite regeneration of the central nervous system.Here is to make a review on the role of MAIs in the central nervous system axonal regeneration,exploring possible treatments to promote the regeneration and function recovery.
出处
《医学综述》
2012年第9期1312-1314,共3页
Medical Recapitulate
关键词
轴突再生
抑制因子
受体
Axonal regeneration
Inhibitory factor
Receptor
