摘要
目的研究乳腺癌超声特征与病理组织学分级及Ki67表达之间的关系。方法回顾分析经病理证实的104个乳腺癌病变，观察其二维及彩色多普勒超声显像特征，用免疫组织化学方法测定肿瘤标本Ki-67表达情况，并分析乳腺癌超声特征与组织学分级及Ki-67表达的关系。结果（1胲组乳腺癌肿块Ki-67阳性表达率为73．1％（76／104）。（2）82个浸润性导管癌肿块（IDC）中，Ⅲ级IDC肿块直径≥2cm及出现Ⅱ～Ⅲ级血流的比率高于Ⅱ级及Ⅰ级IDC肿块，差异有统计学意义（P〈0.05）。（3）Ki-67阳性表达的乳腺癌肿块直径≥2cm、肿块内有微钙化、有腋窝淋巴结转移等的出现比率高于阴性表达的肿块（P〈0．05）。（4）Ⅲ级IDC肿块的Ki-67阳性表达率高于Ⅱ级和Ⅰ级IDC肿块，差异有统计学意义（P〈0．05）。结论乳腺癌的超声特征可以在一定程度上反映其组织学分级及Ki-67的表达水平。
Objective To study the relationship between ultrasound appearance and histologic grades and expression of Ki-67 in breast cancer. Methods The ultrasound appearances of 104 breast carcinomas confirmed by pathology were analyzed. Immunohistochemical method was used to test the expression of Ki-67 in all the breast carcinomas analyzed the relationship between ullrasound appearance and hislologic grades and expression of Ki-67 in breast cancer. Results （ 1 ） The expression rate of Ki-67 were 73.1% （ 76/104 ）. （ 2 ） Among the 82 cases of invasive ductal carcinoma（ IDC ）, appearance rate of diameter ≥2 cm and Ⅱ -Ⅲ grade flow was higher in m grade IDC than in Ⅱ or Ⅰ grade IDC. （ 3 ） Appearance rate of diameter ≥ 2 cm, microcalcification and axillary lymph node metastasis were higher in Ki-67-positive tumors than in Ki-67-negative tumors （ P 〈 0.05 ）. （ 4 ） Expression rate of Ki-67 was higher in Ⅲ grade IDC than in Ⅱ or Ⅰ grade IDC（ P〈 0.05 ）. Conclusion To some extent, uhrasound appearance can reflect the histotogic grade and expression of Ki-67 in breast cancer.
出处
《国际医药卫生导报》
2012年第9期1211-1214,共4页
International Medicine and Health Guidance News
基金
广东省科技厅计划项目经费资助（2010B080702007）
