摘要
目的:评价中药仙灵脾对2型糖尿病大鼠炎症因子的影响。方法:雄性Wistar大鼠70只,从中随机选取10只为正常对照组,其余应用高糖高脂饲料喂养及链脲佐菌素腹腔注射造模,成模2型糖尿病大鼠共44只按血糖值随机分组:糖尿病(DM)模型对照组(16只)、仙灵脾组(16只)、二甲双胍组(12只),各组共相应给药8周,治疗前后取血测量血糖(FBG)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)。结果:成模2型糖尿病各组大鼠FBG,CRP,TNF-α,IL-6水平均较正常对照组大鼠明显增高(P<0.01)。应用仙灵脾及二甲双胍治疗的两组大鼠的FBG,CRP,TNF-α,IL-6水平均较DM模型对照组显著下降(P<0.05),但两治疗组比较差别无统计学意义(P>0.05)。结论:中药仙灵脾治疗2型糖尿病大鼠可降低炎症因子水平,抑制体内炎症反应。
Objective：To investigate the effect of epimedium on inflammatory factor in type 2 diabetic rats.Methods：Ten normal rats（normal control group）was selected from 70 diabetic rats,others was feeded by high-glucose and high-fat diet and injected streptozocin,these models with type 2 diabetic were randomly divided into diabetes mellitus（DM） model group（16 rats）,epimedium group（16 rats） and metformin group（12 rats）.These group were given medical for 8 weeks.We observed their blood glucose（FBG）,C reaction protein（CRP）,tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）.Results：Blood glucose,CRP,TNF-α,IL-6 were significantly higher in type 2 diabetic rats groups than in normal control group（P0.01）.Compared with DM model group,blood glucose,CRP,TNF-α,IL-6 were significantly decreased in epimedium group and metformin group（P0.05）.There was no significant difference between epimedium group and metformin group.Conclusion：Epimedium could reduce the level of inflammatory factor and inhibit inflammatory reaction.
出处
《临床医药实践》
2012年第5期359-361,共3页
Proceeding of Clinical Medicine
关键词
仙灵脾
2型糖尿病
大鼠
炎症因子
epimedium
type 2 diabetes
rats
inflammatory factor
