摘要
目的研究中药北刘寄奴(Siphonostegia chinensis Benth.)的化学成分。方法采用正相硅胶、反相ODS、Sephadex LH-20等柱色谱及高效液相色谱等手段进行分离纯化,并通过理化性质与光谱分析方法鉴定化合物的结构。结果从北刘寄奴体积分数95%乙醇提取物中分离鉴定10个单体化合物,分别为反式对羟基肉桂酸((E)-p-hydroxycinnamic acid,1)、咖啡酸(caffeic acid,2)、syring-in(3)、(7S,8R)-dehydrodiconiferyl alcohol 9'-β-glucopyranoside(4)、vanillyl alcohol-4-O-β-D-gluco-pyranoside(5)、2,6-二甲氧基-4-羟基苯酚-1-O-葡萄糖苷(2,6-dimethoxy-4-hydroxyphenol 1-O-glu-copyranoside,6)、3,5-dimethoxy-4-hydroxybenzyl alcohol 4-O-β-D-glucopyranoside(7)、rubinaphthinA(8)、rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid(9)、(6S,9R)-roseoside(10)。结论化合物2～10为首次从阴行草属植物中分离得到。
Objective To study the chemical constituents from the whole plant of Siphonostegia chinensis Benth..Methods The compounds were isolated by chromatographic methods such as silica gel,ODS,Sephadex LH-20 and HPLC,and identified by the chemical and physical methods,especially spectral analysis.Results Ten compounds were isolated and identified as(E)-p-hydroxycinnamic acid(1),caffeic acid(2),syringin(3),(7S,8R)-dehydrodiconiferyl alcohol 9′-β-glucopyranoside(4),vanillyl alcohol-4-O-β-D-glucopyranoside(5),2,6-dimethoxy-4-hydroxyphenol 1-O-glucopyranoside(6),3,5-dimethoxy-4-hydroxybenzyl alcohol 4-O-β-D-glucopyranoside(7),rubinaphthin A(8),rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo-oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid(9)and(6S,9R)-roseoside(10).Conclusions Compounds 2-10 are isolated from Siphonostergia genus for the first time.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2012年第5期331-336,共6页
Journal of Shenyang Pharmaceutical University
基金
天津市高等学校科技发展基金计划项目(20090201)
国家科技重大专项项目-重大新药创制(2011ZX09307-002-01
2012ZX09103201-031)
教育部留学回国人员科研启动基金资助项目(教外司留[2010]609号)
关键词
阴行草属
北刘寄奴
化学成分
结构鉴定
Siphonostergia genus
Siphonostegia chinensis Benth.
chemical constituent
structure identification
