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Twist、E—cadherin及Vimentin在表达及意义宫颈鳞状上皮癌变的 被引量:5

Expression and significance of Twist and E - cadherin and Vimentin in cervical squamous epithelial cancerization H
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摘要 目的探讨宫颈鳞状上皮癌变过程中Twist、E-cadherin、Vimentin的表达规律及临床意义。方法以慢性宫颈炎为对照,检测宫颈上皮内瘤变(CIN)及宫颈鳞状细胞癌组织标本中Twist(原位杂交)、E-cadherin、Vimentin(SABC免疫组化法)的表达情况,分析其相关性。结果(1)慢性宫颈炎、CINI、CINII、CINIU及宫颈癌组中:Twist的阳性率分别为10.O%、28.1%、29.6%、42.9%、64.3%,其中Twist在宫颈鳞癌的表达均明显高于其他组(P〈0.05)。E-cadherin、Vimentin的阳性率分别为80.O%、68.8%、55.6%、51.4%、39.3%和0、6.3%、7.4%、31.4%、32.1%,其中两者在宫颈鳞癌组、CINⅢ组中的表达与慢性宫颈炎组比较差异均有统计学意义(P〈0.05),(2)分析全部CIN及宫颈癌病例,Twist的表达与E-cadherin呈负相关(r=-0.37,P〈0.01),与Vimentin呈正相关(r:0.23,P〈0.05)。结论宫颈组织中Twist的异常表达与宫颈鳞状上皮癌变发生关系密切,Twist可能通过调控E-cadherin、Vimentin的表达参与宫颈鳞状细胞癌的发生。 Objective To explore the expression rule and clinic significance of Twist and E-cad- herin and Vimentin in cervical squamous epithelial cancerization. Methods Chronic cervicitis were used as control group, the expression of Twist (using hybridization in situ), E-cadherin and Vimentin (SABC im- munohistochemical stain) in tissues of cervical intraepithelial neoplasia (CIN) and cervical squamous carci- noma were detected, and the correlations were analyzed. Results The positive rate of Twist in group of chronic cervicitis, CIN Ⅰ , CIN Ⅱ, CINⅢ and cervical squamous carcinoma was 10. 0% ,28.1% ,29. 6%, 42. 9% and 64. 3%, respectively. The expression rate of Twist in cervical squamous carcinoma group was higher than other groups ( P 〈 0. 05 ). The positive rates of E-cadherin and Vimentin were 80. 0%, 68. 8%, 55.6%, 51.4%, 39. 3% and 0,6. 3% ,7.4% ,31.4% ,32. 1%, respectively. The difference of E-cadherin and Vimentin expression between the cervical squamous carcinoma (or CIN III group) and the chronic eervicitis group was obvious ( P 〈 0.05, respectively). The expression of Twist was negatively cor- related with E-cadherin( r = -0. 37, P 〈0. 01 ), and it was positively correlated with Vimentin in all ca- ses of CIN and cervical squamous carcinoma( r = 0. 23, P 〈 0. 05). Conclusions There is a close rela- tionship between abnormal expression of Twist and cervical squamous epithelial cancerization. Twist may participate in the genesis of cervical squamous carcinoma through mediating the expression of E-cadherin and Vimentin in cervix tissue.
出处 《中国医师杂志》 CAS 2012年第4期473-476,共4页 Journal of Chinese Physician
关键词 Twist转录因子/代谢 钙粘着糖蛋白类/代谢 波形蛋白/代谢 宫颈上皮内瘤样病变/代谢/病理学 鳞状细胞/代谢/病理学 Twist transcription factor/metabolism Cadherins/metabolism Vimentin/metabolism Cervical intraepithelial neoplasia/metabolism/pathology Carcinoma, squamous cell/metabolism/pathology
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