摘要
目的分析探讨HPV联合TCT检测在宫颈疾病筛查中的应用。方法以2017年4月~2018年4月于我院行宫颈疾病筛查的5680例患者作为研究对象,给予患者HPV、TCT及病理学检测。结果共检出1343例高危型HPV患者,感染率为23.64%,所有14类高危型HPV相应基因型均有检出,且35~44岁与45~54岁年龄段相应HPV阳性率比其他年龄段明显偏高(P<0.05),而同时45~54岁年龄范围HPV 16及18型的阳性率均明显高于其他的年龄段(P<0.05);TCT检测有556例表现为阳性且具有临床症状,后经活检最终诊断为阳性患者497例,符合率为89.39%;不同的病理诊断的结果和高危型的HPV感染率、HPV16和18型阳性率以及其他12类高危型的HPV相应阳性率比较,差异均有统计学意义(P<0.05)。结论HPV联合TCT检测能够极大的提升宫颈上皮内瘤变、宫颈癌前病变以及宫颈癌检出率。
Objective To analyze and investigate the application of HPV combined with TCT tests in cervical disease screening.Methods 5680 patients who underwent cervical disease screening at our hospital from April 2017 to April 2018 were selected as the study subjects,and performed with HPV,TCT and pathological tests.Results A total of 1343 high-risk HPV patients were detected,with an infection rate of 23.64%.The corresponding genotypes of all 14 high-risk types of HPV were detected,and the corresponding HPV positive rates of 35 to 44 years old and 45 to 54 years old were significantly higher than those of other age groups(P<0.05),while the positive rates of HPV types 16 and 18 of 45 to 54 years old were significantly higher than those of other age groups(P<0.05);There were 556 positive patients with clinical symptoms in TCT test,and 497 positive patients were finally diagnosed by biopsy,with a coincidence rate of 89.39%;There were statistically significant differences in the results of different pathological diagnoses as well as HPV infection rate of high-risk types,positive rates of HPV types 16 and 18,and corresponding positive rates of 12 other high-risk types of HPV(P<0.05).Conclusion HPV combined with TCT tests can greatly improve the detection rate of cervical intraepithelial neoplasia,precancerous lesions of uterine cervix,and cervical cancer.
作者
李桦
LI Hua(Yangjiang Maternal and Child Health Hospital,Guangdong,Yangjiang 529500,China)
出处
《中国医药科学》
2020年第5期177-179,207,共4页
China Medicine And Pharmacy
