摘要
目的探讨嗜酸粒细胞性支气管炎(EB)和哮喘患者诱导痰微量元素水平的差异及其与气道炎性反应特征的关系。方法检测EB、咳嗽变异性哮喘(CVA)、支气管哮喘患者和健康对照组的诱导痰锌、铜、铁的水平并探讨其与痰炎性反应细胞比例的相关性。结果哮喘组的诱导痰锌、铜浓度显著低于健康对照组、EB和CVA组,差异有统计学意义(P<0.01);铁浓度显著高于健康对照组,差异有统计学意义(P<0.05),也高于EB和CVA组,差异也有统计学意义(P<0.01);CVA组的铜浓度亦显著低于健康对照组,差异有统计学意义(P<0.01)。诱导痰液中嗜酸性粒细胞的比例与锌和铜的水平存在一定的相关性。结论 EB和支气管哮喘患者的诱导痰液中微量元素锌、铜、铁水平存在的显著差异可能是二者病理生理特征差异的机制之一。
Objective To explore the the differences of trace elements level of induced sputum between patients of eosinophilic bronchitis and asthma,and the correlation with airway inflammation features. Methods The level of zinc,copper, and iron of induced sputum in all subjects including patients with EB,CVA, asthma and the control group, and the correlation of trace elements and the proportion of inflammatory cells was investigated. Results Compared with the other three groups,the asthma group had a significant lower level of zinc and copper in induced sputum（P〈0.01）, and it had a much higher level of iron than the control group（P〈0.05）. In addition, in CVA group, the level of copper was remarkably lower than than in control group（P〈0.01）. There was a correlation between the proportion of eosinophils and the level of zinc and copper in induced sputum. Conclusion The significant differences in the level of zinc/copper and iron in induced sputum between asthma and eosinophilic bronchitis patients might be one of the mechanisms that contribute to the physiopathologic differences between the two diseases.
出处
《检验医学与临床》
CAS
2012年第10期1158-1159,1162,共3页
Laboratory Medicine and Clinic
