摘要
目的:从糖尿病多因素致病角度出发,探讨情志因素对2型糖尿病发病的作用机制———气机失调证,以及具有理气降逆散结功效的复方中药心身5号方的调节作用。方法:采用旋转、拥挤、限制3种情志刺激结合腹腔注射少量链脲佐菌素(STZ)的实验方法,制作了2型糖尿病大鼠模型,实验动物分为正常组、应激组、STZ组、应激+STZ组和中药组。检测血浆去甲肾上腺素(NE)、肾上腺素(E)含量,同时观察心身5号方的调节作用。结果:慢性情志应激可促使STZ鼠血浆去甲肾上腺素(NE)、肾上腺素(E)含量升高,其中肾上腺素在应激+STZ组有统计学意义(P<0.01),中药可降低血浆肾上腺素(E)含量。结论:慢性情志刺激引起实验性2型糖尿病大鼠血浆去甲肾上腺素(NE)、肾上腺素(E)含量升高是糖尿病发病机制之一,同时心身5号方有明显调节作用。
Objective： To explore mechanism of action of emotional stimulation on onset of TypeⅡ diabetes, i.c. qi disorder syndrome ; and the regulatory action of Xinshen NO. 5, a compound prescription with effect of regulating qi, countering abnormal ascending qi and dispersing accumulation. Methods：The DM disease was induced in rats by abdominal injecting of small dosage of STZ on top of psycho physiological stimulation （rotation, restraint and crowding）. The subjects were divided to normal group, stress group, STZ group, stim- ulation plus STZ group and Chinese medical treatment group. The serum epinephrine and norepinephrine levels, and the regulatory ac- tion of compound formula Xinshen NO. 5 were observed. Results： Chronic emotional stimulation increased serum epinephrine and norepi- nephrine levels in STZ rats. The stimulation plus STZ group has the highest epinephrine level （ P 〈 O. 01 ）, which could be down regula- ted by the Chinese medicine. Conclusion：Serum epinephrine and norepinephrine increase caused by emotional stimulation is one of the mechanism of type Ⅱ diabetes in rats, on which Xinshen NO. 5 has significant preventing effect.
出处
《世界中医药》
CAS
2012年第2期169-170,共2页
World Chinese Medicine
基金
天津市卫生局中医中西医结合科研项目(200017)
关键词
慢性应激
糖尿病
去甲肾上腺素
肾上腺素
Chronic emotional stimulation
Diabetes
Norepinephrine
Epinephrine
