摘要
拘束负荷动物表现出的应激反应可以部分描述心理应激状态,可以在多靶点整体动物水平上进行观察,在药理学、生理学及病理学等多种研究领域被国内外广泛应用。本文介绍了拘束应激模型的发展历史,概述了国内外有关模型的制作及模型影响因素,综述拘束应激对机体的影响及作用机制,同时结合我们的实际经验提出该模型存在的问题,并对其研究应用前景进行展望。
Animal model of restraint stress shows some of the mental stress responses,and could be observed on entire animal level for multi-target studies.The model is widely applied in pharmacology,physiology and pathology.We introduce the history of restraint stress model,summarize the preparation and influential factors of modeling,and review the impacts induced by stress on the body as well as its mechanism.In addition,we also discuss the problems and prospect based on our experiments.
出处
《中国实验方剂学杂志》
CAS
2008年第11期80-83,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广州市中药现代化研究重大科技专项(2004Z1-E5011)
