摘要
目的 研究地方性砷中毒病情程度与体内砷的蓄积关系。方法 现场临床皮肤改变诊断 ,实验室发砷用原子荧光法检测。结果 1.临床皮肤改变以角化人数最多 ,脱色次之 ,色沉最少。 2 .单体征皮肤改变以单角化为主 ,全部是角化 °;双体征皮肤改变以角化合并其他症状为主 ,主要是角化 °并脱色 °;三体征皮肤改变以角化 °并脱色 °和色沉 °为主 ,以下依次为角化 °并脱色 °和色沉 °、角化 °并脱色 °和色沉 °、角化 °并脱色 °和色沉 °、角化 °并脱色 °和色沉 °以及角化 °并脱色 °和色沉 °。 3.随病情加重 ,病人发砷含量逐渐增高。结论 地方性砷中毒皮肤改变从角化开始 ,先后出现脱色和色沉 ;然后是角化加重或脱色加重 ,最后是色沉加重 ;随病情加重 。
Objective To study the relation between the degree of arsenism patients' skin changes and their hair As level.Methods Clinical check was conducted in endemic area and hair As was determined by atom fluorescent method.Results Clinical results show that 95.3% of patients are affected by hyperkeratosis,91.4% depigmentation and 61.6% hyperpigmentation.Most of single skin change symptoms are hyperkeratosis and all hyperkeratosis are hyperkeratosis Ⅰ°;86.4% of double skin change are hyperkeratosis with other signs and major are hyperkeratosis Ⅰ° with depigmentation Ⅰ°;40.7% of three skin changes are hyperkeratosis Ⅰ° with depigmentation Ⅰ° and hyperpigmentation Ⅰ°.The followings are hyperkeratosis Ⅱ° with depigmentation Ⅰ° and hyperpigmentation Ⅰ°,hyperkeratosis Ⅰ° with depigmentation Ⅱ° and hyperpigmentation Ⅰ°,hyperkeratosis Ⅰ° with depigmentation Ⅱ° and hyperpigmentation Ⅱ°,hyperkeratosis Ⅱ° with depigmentation Ⅱ° and hyperpigmentation Ⅱ°,and hyperkeratosis Ⅲ° with depigmentation Ⅲ°.With the symptoms getting serious,hair As content increases gradually.Conclusions Skin changes of arsenism begin from hyperkeratosis,next affected by depigmentation and hyperpigmentation.Then hyperkeratosis or depigmentation gets serious,and last hyperpigmentation gets serious.Hair As content increases gradually with symptoms getting serious. [
出处
《中国地方病学杂志》
CAS
CSCD
2000年第1期62-64,共3页
Chinese Jouranl of Endemiology
基金
中国科学院"九五"重大项目资助 ! KZ95 1-b1-2 0 4
