摘要
目的:研究双秦眼用凝胶体外释放特性。方法:以秦皮甲素为指标,采用高效液相法进行含量测定;采用改良的Franz扩散池法,以半透膜为释放膜,研究双秦眼用凝胶的体外释放特性。结果:双秦眼用凝胶中秦皮甲素的释放以一级模型拟合较好,拟合方程Y=-1.258 8 X-0.816 2(r=0.999 2)。结论:双秦眼用凝胶释放为非Fick扩散。
Objective：To study on in vivo releasing characteristics of Shuangqin eye gel.Method： The content of aesculin was determined by HPLC,which was used as index;Modified Franz diffusion cell method was applied to investigate in vitro release characteristics of Shuangqin eye gel with semi-permeable membrane as a barrier.Result： Aesculin in Shuangqin eye gel released fitted well with first order model,fitting equation of it：Y=-1.258 8 X-0.816 2（r=0.999 2）.Conclusion： Release of Shuangqin eye gel was non-Fick diffusion.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第8期9-11,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
重大新药创制科技专项(20092X09301-005)
