摘要
目的：建立复方丹参缓释片总丹酚酸释放度的紫外测定方法，评价其释药行为。方法：用紫外分光光度法和释放度试验，以丹酚酸B为对照品，测定复方丹参缓释片中总丹酚酸在不同释放时间的累积释放度。结果：丹酚酸B对照品在286nm有最大吸收，在4．9～98μg／mL范围内与吸收度呈良好的线性关系（A=0．0207C-0．0321，r=0．9998），总丹酚酸体外释药行为符合Higuchi方程：Mt／M∞=0．3408t^1/2-0．117，r=0．9966。结论：本法简便、快速，可用于控制复方丹参缓释片的质量。
AIM： To establish a UV method of determing the dissolution of total salvianolic acid of Compound Danshen sustained-release Tablets, and to evaluate its release behavior. METHODS： With the salvianolic acid B as standard, ultraviolet spectrophotometry and the release test were applied to determine the dissolution of total salvianolic acid of Compound Danshen sustained-release Tablets in distinct dissolution. RESULTS： Salvianolic acid B had the maximum absorption peak at 286 nm, and a good linearity within the range of d. 9 - 98 μg/mL（ A = 0.0207C -0. 0321 ,r =0. 9998）, and total salvianolic acid had a good dissolution fit with Higuchi Square Mt/M∞=0. 3408t^1/2 -0. 117 ,r =0. 9966. CONCLUSION： The UV method is simple, quick, and can be used for quality control of the preparation.
出处
《中成药》
CAS
CSCD
北大核心
2006年第5期636-638,共3页
Chinese Traditional Patent Medicine
基金
国家自然基金课题(编号:30472198)
国家中医药管理局课题(编号:04-05ZP50)
广东省自然基金课题(编号:04105450)
关键词
复方丹参缓释片
总丹酚酸
释放度
紫外分光光度法
Compound Danshen sustained-release Tablets
total salvianolic acid
dissolution degree
ultraviolet spectrophotometry
