摘要
目的:研究软肝消水巴布剂的成型工艺,体外透皮行为及其释放规律。方法:采用正交设计,利用离体大鼠皮肤透过试验,优化软肝消水巴布剂的基质配方;采用Franz’s扩散池法,考察透皮促进剂氮酮、丙二醇对人参皂苷Rg1的促渗透能力;采用桨碟法,考察释药规律。结果:软肝消水巴布剂中人参皂苷Rg1的透皮速率为0.394μg/cm2/h(大鼠皮肤),12 h能累积释放90%以上,释放规律符合一级模型。结论:软肝消水巴布剂中人参皂苷Rg1的释放速度大于透过皮肤的速度,为皮肤控释型制剂,加入复合促渗透剂能提高药物的透皮速率。
AIM： To study the prepartion of Ruanganxiaoshui Cataplasma and it＇ s percutaneous absorption in vitro as well as dissolvability in vitro. METHODS： In the experiment, orthogonal test was used to optimize the preparation. Meanwhile, with the help of azole and propylene alcohol the percutaneous absorption of ginsenoside Rg1 from the cataplasma carriers in vitro was determined by Franz＇ s diffusion cell and HPLC, as well as dissolution rate in vitro. RESULTS ： The percutaneous absorption rate of ginsenoside Rg1 through rat skin in vitro was 0. 394 μg/cm^2/h. And the dissolution process fitted to first order model. CONCLUSION： The Cataplasma carriers possess a good drug dissolution property. To add compound penetration enhancers is one of the effective methods for raising percutaneous absorption.
出处
《中成药》
CAS
CSCD
北大核心
2007年第10期1431-1434,共4页
Chinese Traditional Patent Medicine
关键词
软肝消水巴布剂
人参皂苷RG1
体外累积释放度
体外透皮吸收
Ruanganxiaoshui Cataplasma
ginsenoside Rg1
accumulative dissolution rate in vitro
percutaneous absorption in vitro
