摘要
目的探讨2型糖尿病肾病与血同型半胱氨酸的关系及叶酸对上述两者的作用。方法选取2009～2011年符合2型糖尿病诊断的门诊、住院患者连续入选为研究对象,收集有效病例60例,并按糖尿病肾病严重程度分组,同时收集体检对照者资料20例,分别测定血同型半胱氨酸等指标,以判断糖尿病肾病与同型半胱氨酸的关系;监测叶酸治疗前后血同型半胱氨酸、肾功能的变化,明确叶酸对上述两者的影响作用。结果 2型糖尿病各组病人血同型半胱氨酸显著高于体检对照组、糖尿病肾病组血同型半胱氨酸显著高于糖尿病尿蛋白正常组(P<0.05);叶酸治疗后T2DM各组血同型半胱氨酸、血肌酐显著下降(P<0.05)。结论高同型半胱氨酸与2型糖尿病肾病有关,其机制可能是通过血管内皮损伤所致;补充外源性叶酸在一定的程度上降低血同型半胱氨酸水平、改善肾功能。
Objective To investigate the relationship between homocysteine and diabetic nephropathy;The effect of folic acid treatment of the patients.Methods All T2DM patients in deparment of endocrinology of Jiangmem central hospital were consecutively recruited from 2009 to 2011.A total of 60 T2DM and 20 healthy controls were inciuded.Homocysteine and other index were examined before and after folic acid treatment to investigate the relationship between homocysteine and diabetic nephropathy.Results The homocysteine in all T2DM was significantly higher than that of controls（P0.05）;The homocysteine in DN was significantly higher than that of T2DM without renal function abnorma（P0.05）;After folic acid treatment,The homocysteine and serum creatinine in all T2DM were significantly lower than before（P0.05）.Conclusion ①Hyperhomocysteinemia is related to the diabetic nephropathy,and endothelial dysfunction may be involved in its pathogenesis.②Folic acid treatment may be lower homocysteine and reduce its damage to the renal function of T2DM.
出处
《中国热带医学》
CAS
2012年第2期210-212,共3页
China Tropical Medicine
基金
江门市科研课题项目
No江科【2011】89号91
关键词
糖尿病肾病
同型半胱氨酸
肾功能
叶酸
尿白蛋白排泄率
Diabetic nephropathy
Homocysteine
Renal function
Folic acid
Urine albumin excretion
