摘要细胞外调节蛋白激酶（extracellular regulated protein kinases,ERK）分为ERK1和ERK2,是丝裂原活化蛋白激酶系统（mitogen-activated protein kinases,MAPKs）的重要组成之一。ERK1/2主要被生长因子、物理射线、过氧化氢、
6Lai EC.Notch signaling:control of cell communication and cell fate.Development,2004,131 (5):965-973 被引量：1
7Greenspan DL,Connolly DC,Wu R,et al.Loss of FHIT expression in cervical carcinoma cell lines and primary tumors.Cancer Res,1997,57:4692-4698 被引量：1
8Lin HH,Chen JH,Huang CC,et a1.Apoptotic effect of 3,4-dihydroxy-benzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation.1nt J Cancer,2007,120 (11):2306-2316 被引量：1
9Huang HM,Chiou HY,Chang,et a1.Activin A induces erythroid gene expressions and inhibits mitogenic cytokine-mediated K562 colony formation by activating p38 MAPK.J Cell Biochem,2006,98 (4):789-797 被引量：1
10Iyoda K,Sasaki Y,Horimoto M,et al.Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma.Cancer,2003,97 (12):3017-3026 被引量：1
3Wilms H, Zecca L, Rosenstie[ P, et al. Inflammation in Par- kinson's diseases and other neurodegenerative diseases: cause and therapeutic implications [J]. Curr Pharm Des, 2007, 13 (18):1925-1928. 被引量：1
4Phani S, Loike J D, Przedborski S. Neurodegeneration and in- flammation in Parkinson' s disease [J]. Parklnsonism Relat Disord, 2012 ,18(Suppl 1):S 207-S 209. 被引量：1
5Nichols A, Camps M, Gillieron C, et al. Substrate recognition domains within extracellular signal-regulated kinase mediate binding and catalytic activation o: mitogen-activated protein ki- nase phosphatase-3[J]. J Biol Chem, 2000,275 (32) : 24613 - 24621. 被引量：1
6Taylor T N, Greene J G, Miller G W. Behavioral phenotyping of mouse models of Parkinson's disease[J]. Behav Brain Res, 2010,211(1) :1-10. 被引量：1
7Eberhardt O, Schulz J B. Apoptotic mechanisms and anti- apoptotic therapy in the MPTP model of Parkinson:s disease [J]. Toxicol Lett, 2003,139 (2/3) : 135- 151. 被引量：1
8S6guin C A, Boiarski M, Pilliar R M, et al. Differential regu- lation of matrix degrading enzymes in a TNF a-induced mo- del of nucleus pulposus tissue degeneration[J]. Matrix Biol, 2006,25(7) : 409-418. 被引量：1
9Mogi M, Togari A, Kondo T, et al. Caspase activities and tumor necrosis factor receptor R I(P 55) level are elevated in the substantia nigra from Parkinsonian brain[J]. J Neural Transm, 2000,107 (3) : 335- 341. 被引量：1
10McGeer P L, Yasojima K, McGeer E G. Association of inter- leukin-1 beta polymorphisms with idiopathic Parkinson:s di sease [J]. Neurosci Lett,2002:326(1) :67-69. 被引量：1
