摘要
目的探讨脑梗死患者脑脊液中白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)的含量与脑梗死及其预后的关系。方法选取2009年6月-2010年6月收治的脑梗死患者50例为观察组,随机选取同期健康体检正常者30例为对照组。检测对照组及观察组入院第3天的脑脊液中IL-6、TNF-α的含量,并分析IL-6、TNF-α含量与认知功能缺陷的关系。结果观察组脑脊液中IL-6、TNF-α含量明显高于对照组(P<0.05),与脑梗死体积呈显著正相关(P<0.05),而与认知功能缺陷无显著相关(P>0.05)。结论检测脑梗死中脑脊液中IL-6、TNF-α对判断脑损伤程度有重要意义,但不能直接反映认知功能。
[ Objective ] To investigate the relation between interleukin-6 （IL-6）, tumor necrosis factor （TNF-α） levels in cerebrospinal fluid with cerebral infarction and its prognosis in cerebral infarction patients.[Methods] 50 patients with cerebral infarction admitted to in our hospital from June 2009 to June 2010 were as the observation group, and randomly selected 30 cases normal healthy as the control group over the same period in our hospital clinic. To detect the IL-6, TNF-α level in cerebrospinal fluid of control group and observation group at 3days after admission, and analysis the relationship between of IL-6, TNF-α levels and cognitive dysfunction. [ Results ] The IL-6, TNF-α levels in cerebrospinal fluid of observation group were significantly higher than that of control group （P 〈0.05）, and it was significantly positive correlation with infarct volume （P 〈0.05）, but it has no significant correlation with cognitive function defects （P 〉0.05）. [ Conclusion ] The detection of IL-6, TNF-α level in cerebrospinal fluid in cerebral infarction is important to judge the extent of brain damage, but could not directly reflect the cognitive function.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第3期69-71,共3页
China Journal of Modern Medicine
