摘要
目的:探讨胆管癌组织蛋白磷酸酶2A的癌性抑制因子(CIP2A)和Survivin蛋白的表达情况及其临床意义。方法:采用免疫组织化学方法,检测57例胆管癌组织和23例癌旁正常胆管组织中CIP2A和Survivin蛋白的表达情况,采用SPSS 13.0软件分析CIP2A和Sur-vivin蛋白表达与临床特征的关系以及可能对生存的影响。结果:在胆管癌组织中CIP2A和Survivin蛋白表达均高于癌旁正常胆管组织,差异有统计学意义,P<0.05。胆管癌组织中CIP2A和Survivin蛋白的表达呈正相关;CIP2A蛋白的表达与胆管癌组织的分化程度、TMN分期等均无关,P>0.05;Survivin蛋白的表达与胆管癌组织的分化程度、TNM分期和淋巴结转移有关,P<0.05。Kaplan-Meier生存分析表明,CIP2A和Survivin蛋白阳性表达组患者的总体生存时间短于阴性表达患者组,差异有统计学意义,P<0.05;Cox多因素回归分析显示,CIP2A和Survivin蛋白表达是胆管癌患者预后的独立因素,P<0.05。结论:胆管癌组织中CIP2A和Survivin的表达存在正相关,CIP2A和Survivin蛋白表达可能是胆管癌生存的独立影响因子。
OBJECTIVE： To explore the expression of CIP2A and Survivin,and evaluate their clinicopathological significance in patients with cholangiocarcinoma.METHODS： The immunohistochemical analysis was used to analyze the CIP2A and Survivin expression in 57 cases of cholangiocarcinoma and 23 cases of adjacent noncancerous normal bileduct tissues.Statistical analysis was used to evaluate the expression of CIP2A and Survivin in relation to the clinicopathological features and prognosis by SPSS13.0 software.RESULTS： CIP2A and Survivin expression in cholangiocarcinoma tissues was more than that in adjacent noncancerous normal bile duct tissues（P0.05）.The expression of CIP2A was not related with TNM stage,differentiation and lymphnode metastas（P0.05）.But the expression of Survivin was found to be linked with TNM stage,differentiation and lymphnode metastas（P0.05）.Basis on CIP2A or Survivin expression,the data showed that there was a statistically difference about the overall survival time by Kaplan-Meier analysis（P0.05）.By Cox regression analysis,the CIP2A expression and Survivin expression were the independent prognostic factors（P0.05）.CONCLUSION：It shows that the expression of CIP2A may be positive correlated with the expression of Survivin,CIP2A and Survivin protein expression are the independent prognostic factors.
出处
《中华肿瘤防治杂志》
CAS
2011年第24期1933-1937,共5页
Chinese Journal of Cancer Prevention and Treatment
