期刊文献+

2型糖尿病视网膜病变患者血浆同型半胱氨酸的变化及临床意义 被引量:3

The changes and clinical significance of plasma homocysteine and type 2 diabetic retinopathy
下载PDF
导出
摘要 目的探讨血浆同型半胱氨酸(Hcy)与2型糖尿病视网膜病变(DR)的关系。方法测定15例健康对照者,18例2型糖尿病无DR患者(NDR组),27例2型糖尿病伴背景型视网膜病变者(BDR组),及25例2型糖尿病伴增生型视网膜病变者(PDR组)血浆Hcy水平。结果血浆Hcy含量在正常对照组及NDR组、BDR组、PDR组浓度依次增高,且两两比较差异有统计学意义(P<0.05)。结论血浆Hcy可能参与了糖尿病视网膜病变的发病,可望为糖尿病视网膜病变的防治提供新的方向。 Objective: To investigate the relationship of plasma homocysteine(Hcy) and type 2 diabetic retinopathy.Methods: Plasma Hcy level was measured in 70 diabetic and 15 normal subjects.Results: The levels of Hcy in plasma in the normal control group,NDR group,BDR group and PDR group were increased gradually,and pairwise comparisons were significantly different(P0.05).Conclusion: Hcy may be involved in the pathogenesis of diabetic retinopathy.It is expected to provide the prevention and treatment of diabetic retinopathy in a new direction.
作者 刘国丽 郑骁
出处 《泰山医学院学报》 CAS 2011年第12期911-913,共3页 Journal of Taishan Medical College
关键词 糖尿病 视网膜病变 血浆同型半胱氨酸 homocysteine diabetic retinopathy diabetes mellitus
  • 相关文献

参考文献5

  • 1Hoogeveen EK,Kostense PJ,Eysink PE,et al.Hyperhomocysteine-mia is associated with the presence of retinopathy in type2diabetes mellitus:The Hoom Study[J].Arch Intern Med,2000,160(19):2984-2990. 被引量:1
  • 2Li Zh,Su So.The Relationship between the serum Hyperhomo cysteinemia and the senile insulin resistance with diabetic retinopa-thy in the elderly[J].Chinese Journal of Gerontology,2009,11(29):2713-2714. 被引量:1
  • 3王绵,李凤英,葛秀兰.高同型半胱氨酸血症与胰岛素抵抗及糖尿病慢性并发症[J].国外医学(内分泌学分册),2001,21(3):146-149. 被引量:46
  • 4Toshimitsu S,Kestke F,Osamt Y.Homocysteine enhances en-dathelial apoptosis via upregulation of fas-mediated pathways[J].Hypertension,2004,43:1208-1213. 被引量:1
  • 5Kathy KW,Yeung A,Conniew H,et al.Hyperhomocysteinemiaactivates nuclear factor-κβin endothelial cells viaoxidative stress[J].Circ Res,2004,94:28-36. 被引量:1

二级参考文献1

  • 1A. Chico,A. Pérez,A. Córdoba,R. Arcelús,G. Carreras,A. de Leiva,F. González-Sastre,F. Blanco-Vaca. Plasma homocysteine is related to albumin excretion rate in patients with diabetes mellitus: a new link between diabetic nephropathy and cardiovascular disease?[J] 1998,Diabetologia(6):684~693 被引量:1

共引文献45

同被引文献39

引证文献3

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部