摘要
目的探讨2型糖尿病围绝经期女性周围血管病变与氧化应激的关系。方法选取2015年1月-2018年1月在我院接受治疗的2型糖尿病合并周围血管病变患者60例(T2DM伴周围血管病变组)、单纯2型糖尿病患者60例(T2DM组),同时选取健康志愿者60例作为对照组,检测各组超氧化物歧化酶(SOD)、丙二醛(MDA)、同型半胱氨酸(Hcy)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、平均血糖波动幅度(MAGE)及踝肱指数(ABI)。结果 T2DM伴周围血管病变组MDA和Hcy分别为(5.83±0.99)nmol/ml和(18.72±3.10)mol/L,明显高于对照组和T2DM组(P<0.05),而SOD为(81.30±21.02)U/ml,明显低于对照组和T2DM组(P<0.05);T2DM伴周围血管病变组MAGE为(5.02±1.18)mmol/L,明显高于对照组和T2DM组(P<0.05);T2DM组和T2DM伴周围血管病变组FBG和HbA1c比较差异无统计学意义(P>0.05);T2DM伴周围血管病变组ABI为(0.76±0.11),明显低于对照组和T2DM组(P<0.05);MDA、Hcy与MAGE呈正相关(r=0.462、0.456,P<0.05),而与ABI呈负相关(r=-0.571,P<0.05);SOD与MAGE呈负相关(r=-0.447,P<0.05),而与ABI呈正相关(r=0.470,P<0.05)。结论氧化应激反应在2型糖尿病围绝经期女性周围血管病变中有重要作用,且与患者血糖波动有相关性,值得进一步研究。
Objective To investigate the relationships between peripheral vascular disease and oxidative stress in perimenopausal women with type 2 diabetes mellitus. Methods Between January 2015 and January 2018,60 patients with type 2 diabetes combined with peripheral vascular lesions（ T2DM with peripheral vascular lesions group） and another 60 patients with type 2 diabetes mellitus（ T2DM group） were selected,while 60 healthy volunteers were selected as the control group. Levels of superoxide dismutase（ SOD）,malondialdehyde（ MDA）,homocysteine（ Hcy）,fasting blood glucose（ FBG）,glycated hemoglobin（HbA1c）,mean amplitude of glycemic excursions（ MAGE） and ankle brachial index（ ABI） were detected in each group. Results The MDA and Hcy in T2DM with peripheral vascular lesions group were（ 5.83±0.99） nmol/ml and（ 18.72±3.10） mol/L respectively,which were significantly higher than those of control group and T2DM group（ P〈0.05）,but SOD was（ 81.30±21.02） U/ml,significantly lower than that of control group and T2DM group（ P〈0.05）. The MAGE of T2DM with peripheral vascular disease group was（ 5.02±1.18） mmol/L,which was significantly higher than that of the control group and T2DM group（ P〈0.05）. There was no significant difference in FBG orHbA1c between T2DM group and T2DM with peripheral vascular disease group（ P〈0.05）. The ABI of T2DM with peripheral vascular disease group was（ 0.76±0.11）,which was significantly lower than that of control group and T2DM group（ P〈0.05）. MDA and Hcy were positively correlated with MAGE（ r= 0.462,0.456,P〈0.05）,but negatively correlated with ABI（ r=-0.571,P〈0.05）. SOD was negatively correlated with MAGE（ r =-0.447,P〈0.05）,but positively correlated with ABI（ r = 0.470,P〈0.05）. Conclusion Oxidative stress plays an important role in the peripheral vascular disease of type 2 diabetes mellitus in perimenopausal women,and is related to blood glucose fluctuations.
作者
宋娜
苏峰
高宇
刘晓燕
韩桂艳
刘畅
李丽慧
SONG Na;SU Feng;GAO Yu;LIU Xiaoyan;HAN Guiyan;LIU Chang;LI Lihui(Department of Endocrinology,Affiliated Hospital of Chengde Medical College,Chengde Hebei 067000,Chin)
出处
《解放军预防医学杂志》
CAS
2018年第7期883-885,928,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
承德市科学技术局项目(No.20151040)
关键词
氧化应激
2型糖尿病
围绝经期
周围血管病变
oxidative stress
type 2 diabetes mellitus
perimenopause
peripheral vascular disease
