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六种动脉粥样硬化标志物的研究进展 被引量：10

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摘要 心血管疾病（cardiovascular disease，CVD）占全球致死疾病的50％，是西方国家的主要死亡原因^[1]。近年来，由于国人饮食与生活习惯的改变，动脉粥样硬化（atherosclerosis，As）在我国的发病率和死亡率均逐年上升且呈“年轻化”趋势。1999年，Ross^[1]。提出了“AS是一种炎症性疾病”的学说，认为As是源于内皮功能障碍的慢性、进行性、炎症性疾病，其形成因素包括细胞聚集和增殖、斑块形成、血管重塑、炎症反应及纤维组织增生导致的血管病变等。因为早发AS总是出现在CVD发展之前，所以相关的标志物的检测非常重要。本文就几种与As相关的标志物及其研究进展加以综述。
作者 季茳 张春妮
机构地区 南京军区南京总医院解放军临床检验医学研究所检验科
出处 《标记免疫分析与临床》 CAS 2012年第1期59-62,共4页 Labeled Immunoassays and Clinical Medicine
基金 国家自然科学基金(NSFC 30950100)
关键词 动脉粥样硬化 心血管疾病 标志物 同型半胱氨酸 C反应蛋白 3纤维蛋白原 载脂蛋白B 载脂蛋白A-I 脂蛋白相关磷脂酶A2 微小核糖核酸
分类号 R541.4 [医药卫生—心血管疾病] R446 [医药卫生—内科学]
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参考文献12

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二级参考文献29

共引文献19

同被引文献88

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标记免疫分析与临床
2012年 第1期

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