摘要
目的探讨老年高血压病患者血浆β2微球蛋白(β2-MG)、踝臂指数(ABI)与血压变异性(BPV)的关系。方法选取原发性老年高血压病患者423例,根据β2-MG水平分为β2-MG<2 mg/L组、β2-MG≥2 mg/L组,比较两组间BPV的差别;另根据ABI值分为ABI<0.9组、ABI≥0.9组,比较两组间BPV和血浆β2-MG的差别。分别以24 h收缩压变异率(24h SBPV)、24 h舒张压变异率(24h DBPV)为因变量,其他变量为自变量,采用逐步回归的方法建立回归模型,分析血浆β2-MG、ABI值与BPV的关系。结果β2-MG≥2 mg/L组24h SBPV、24h DBPV、24h平均动脉压较β2-MG<2 mg/L组显著增高(23.33%±5.12%比20.39%±4.74%,17.10%±4.98%比15.40%±4.60%,94.36±12.33 mm Hg比90.67±14.52 mm Hg,均P<0.001);ABI<0.9组24h SBPV、24h DBPV、血浆β2-MG水平较ABI≥0.9组显著增高(24.34%±6.02%比19.45%±5.49%,17.27%±5.18%比14.62%±4.95%,2.87±1.20 mg/L比1.56±0.85 mg/L,均P<0.001)。多元线性回归分析显示:24h SBPV与年龄、血浆β2-MG、低密度脂蛋白呈正相关,与ABI呈负相关;24h DBPV与年龄、血浆β2-MG呈正相关,与ABI呈负相关。结论老年高血压患者BPV随年龄增长而增大,BPV增高可加重动脉粥样硬化程度,并且与靶器官损害程度密切相关。
Aim To investigate the relationship between plasma β2-microglobulin（ β2-MG）,ankle-brachial index（ ABI） and blood pressure variability（ BPV） in elderly patients with hypertension. Methods 423 elderly patients with essential hypertension were selected. According to the plasma level of β2-MG,the patients were divided into two groups：β2-MG 〈2 mg/L group and β2-MG≥2 mg/L group,and BPV difference was compared between the groups. In addition,according to the ABI value,the patients were divided into two groups： ABI〈 0. 9 group and ABI≥0. 9 group,and the differences of BPV and β2-MG were compared between the groups. Respectively taking 24 h systolic blood pressure variability（ 24 h SBPV） and 24 h diastolic blood pressure variability（ 24 h DBPV） as the dependent variable,other variables as independent variable,the regression models were established by stepwise regression method to analyze the relationship between plasmaβ2-MG,ABI and BPV. Results 24 h SBPV,24 h DBPV and 24 h mean artery blood pressure in β2-MG≥2 mg/L group were significantly higher than those in β2-MG 〈2 mg/L group（ 23. 33% ± 5. 12% vs 20. 39% ± 4. 74%,17. 10% ± 4. 98%vs 15. 40% ± 4. 60%,94. 36 ± 12. 33 mm Hg vs 90. 67 ± 14. 52 mm Hg,all P〈0. 001）. 24 h SBPV,24 h DBPV and plasmaβ2-MG level in ABI 〈0. 9 group were significantly higher than those in ABI≥0. 9 group（ 24. 34% ± 6. 02% vs 19. 45% ± 5.49%,17. 27% ± 5. 18% vs 14. 62% ± 4. 95%,2. 87 ± 1. 20 mg/L vs 1. 56 ± 0. 85 mg/L,all P〈0. 001）. Multiple linear regression analysis showed that 24 h SBPV was positively correlated with age,plasma β2-MG level and low density lipo-protein,and negatively correlated with ABI,24 hD BPV was positively correlated with age,plasma β2-MG level,and negatively correlated with ABI. Conclusions In elderly patients with hypertension,BPV increases with age. The increase of BPV can aggravate the degree of atherosclerosis,and is closely related to the degree of target organ damage.
作者
李伟
王义围
王淼
赵翠
王璐
王国玉
LI Wei WANG Yi-Wei WANG Miao ZHAO Cui WANG Lu WANG Guo-Yu(Department of Geriatrics, the Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, Chin)
出处
《中国动脉硬化杂志》
CAS
北大核心
2016年第10期1031-1034,共4页
Chinese Journal of Arteriosclerosis
关键词
老年
原发高血压病
血浆β2微球蛋白
踝臂指数
血压变异性
Elder
Primary Hypertension
β2-Microglobulin
Ankle-brachial Index
Blood Pressure Variability
