摘要
目的 通过对顽固性颞叶癫痫病人的质子波谱 (1HMRS)和磁共振成像 (MRI)研究 ,探讨这两种方法对癫痫灶定位诊断的作用。方法 2 2例无颞叶占位的癫痫病人和 3 0例健康志愿者分别进行了1HMRS采集和MRI扫描后海马结构定量研究 ,分析NAA/Cr +Cho和DHF在癫痫组的改变及对癫痫组定侧定位的敏感性和特异性。结果 1HMRS可对 16例病人进行定侧诊断 ,并发现 10例有双侧颞叶病变。MRI可准确判断 10例海马萎缩。结论 1HMRS对颞叶癫痫定侧敏感性高于海马体积测量 ,并能发现双侧病变 ;MRI海马结构定量发现海马硬化特异性较高。
Purpose To determine the relative utility of 1HMRS and MRI for presurgical lateralization of temporal lobe epilepsy(TLE) by the study of metabolic abnormalities and anatomical alterations in the brain of patients with TLE. Methods 1HMRS and MRI were performed on 22 patients with TLE of non mass lesion origin and 30 healthy volunteers on 2 0 T MRI/MRS system.The ratio of NAA/Cr+Cho was measured and the difference of hippocampal formation(DHF)was calculated.NAA/Cr+Cho and DHF were analyzed for evaluation of the sensitivity and specificity of lateralizing seizure origin. Results On the basis of the NAA/Cr+Cho ratio,we achieved lateralization in 17 cases,10 cases showing bilateral abnormalities with the ipilateral side more severe than the contralateral side.According to the 95% normal reference range DHF(-0 19～0 41),10 of these patients showed hippocampal atrophy. Conclusion 1HMRS was more sensitive than MRI volumetric measurement in lateralizing seizure origin,but MRI was more specific than 1HMRS. [
出处
《中国医学影像技术》
CSCD
北大核心
2000年第2期103-105,共3页
Chinese Journal of Medical Imaging Technology
关键词
颞叶癫痫
海马
磁共振成像
质子波谱分析
癫痫
Temporal lobe epilepsy
Hippocampus
Magnetic resonance imaging
Magnetic resonance spectroscopy
