摘要
目的探讨不同脂肪酸饮食对糖耐量正常人群内脏脂肪素(Visfatin)的影响及其与胰岛素抵抗之间的关系。方法 30例糖耐量正常受试者食用不同类型脂肪酸饮食,分为3组,饱和脂肪酸饮食(S)组、单不饱和脂肪酸饮食(M)组、多不饱和脂肪酸饮食(P)组,饮食干预后分别进行OGTT实验,检测外周血清Visfatin、TC、TG、HDL-C、LDL-C,稳态模型胰岛素抵抗指数(HOMA-IR)来评估胰岛素敏感性。结果不饱和脂肪酸组的FPG、TC、LDL-C、apoB显著降低,3组间TG、HDL-C、VLDL、apoA、AUCglu、HOMA-β及其余时间点的血糖差异均无统计学意义(P>0.05)。与M组相比,S组和P组的FIns、HOMA-IR、AUCIns显著升高,空腹Visfatin显著降低(P<0.05或P<0.01),60min时M组相比S组Visfatin显著降低(P<0.01)。Visfatin与HOMA-IR呈明显负相关(r=-0.458,P<0.05)。结论单不饱和脂肪酸饮食可以升高Visfatin水平,以改善胰岛素抵抗。
Objective To study the effects of distinguished type of dietary fat acids on insulin resistance and visfatin in NGT adults.Methods 30 NGT adults were devided into three groups： polyunsaturated fatty acid（P）,saturated fatty acid（S）,monounsaturated fatty acid（M）.At the end of fattyintervention, OGTT,fasting serum visfatin,TC、TG、HDL-C、LDL-C were assayed.Insulin sensitivity was evaluated by HOMA-IR. Results The level of serum FPG,TC,LDL,apoB was significantly lower in M group and P group than in S group（P〈0.05）,but TG,HDL,VLDL,apoA,AUCg,HOMA-B and glucose at other times had no difference（P〈0.05）.Serum visfatin level was negatively correlated with HOMA-IR.Multiple regression analysis showed that visfatin was an independent relative factor for HOMA-IR. Conclusions Monounsaturated fatty acids（MUFA） can increase the plasma level of visfatin,which suggests that MUFA-rich diet might have anti-atherosclerosis effects, and might improve insulin sensitivity.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2012年第1期17-19,共3页
Chinese Journal of Diabetes
