摘要
目的通过给予糖耐量正常受试者不同类型脂肪酸饮食,探讨其对肠促胰岛素(incretin)、胰岛β细胞功能的影响。方法采用自身对照研究,15例健康受试者经标准饮食洗脱1周后,接受高饱和脂肪酸饮食(HSF)、高不饱和脂肪酸饮食(HMF)之一作为早餐摄入,然后再采用标准饮食洗脱1周,重复试验过程,分别进食两种不同的营养餐。测定进餐后0、30、60、120、180、240 min血糖、血脂、游离脂肪酸、胰岛素、抑胃多肽(gastric inhibitory polypeptide,GIP)和胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)水平。评估不同类型脂肪酸对肠促胰岛素、胰岛β细胞功能的影响。结果曲线下面积(AUC)分析,进餐后HSF组、HMF组血糖水平无明显改变,两组间差异无统计学意义(P>0.05)。HSF组与HMF组相比,AUCins240min、AUCTG240min和AUCFFA240min均增高,差异具有统计学意义(P<0.05)。进餐后,HSF组与HMF组相比,AUCGIP30min、AUCGIP240min、AUCGLP-1 30min和AUCGLP-1 240min均减低,差异有统计学意义(P<0.05)。胰岛β细胞功能指数分析,两组间ΔI30/ΔG30差异无统计学意义(P>0.05)。HSF组与HMF组相比,AUCI/AUCG增高,差异有统计学意义(P<0.05)。结论健康青年人群中不同类型脂肪酸饮食可影响GIP、GLP-1分泌及胰岛功能变化。此外,高不饱和脂肪酸饮食促进GIP、GLP-1分泌作用最明显,但高饱和脂肪酸饮食可促进更多胰岛素的分泌,胰岛β细胞功能指数也明显增高。
Objective To explore the effect of dietary fat acids on incretin and islet function in healthy adults. Methods Before each test, healthy subjects received a 1-week pre-experiment eucaloric diet. Fifteen subjects consumed two meals containing different fat acids, including high saturated fat acid （HSF） and high monounsaturated fat acid （HMF）. On two separate occasions,they underwent a minimum of 1-week washout between meals. At 0,30,60,120,180 and 240 min following meal intake, the plasma concentrations of gastric inhibitory polypeptide（ GIP）, glucagon-like peptide-1 （ GLP-1 ） and serum concentrations of glucose, insulin, triglycerides （TG） and free fatty acid （FFA） were measured. Results Postprandial glucose did not increase significantly following HSF and HMF meals （P 〉 0.05 ）. Compared with HMF meal, significant increase in AUCins240min ,AUCTG2a0min and AUCrFA24ominwas observed following HSF meal （P 〈 0.05 ）. Compared with HMF meal, a significant decrease in AUCGi^Omin, AUCG[P240mln, AUCGLp.130rain and AUCGLp.l 240min was found following HSF meal （P 〈0.05）. No significant difference was observed inAI30/AG30following HSF and HMF meals （P 〉 0.05）. AUC1/AUCc was significantly lower following HMF meal as compared with HSF meal （P 〈 0.05）. Conclusion This study demonstrates that the function of GIP, GLP-1 and 13 cell is affected by the dietary fat acids in healthy adults. The HMF meal may stimulate GIP and GLP-1 secretion to a greater extent than HSF meal.
出处
《军事医学》
CAS
CSCD
北大核心
2015年第10期769-772,786,共5页
Military Medical Sciences
基金
中华医学会临床医学科研专项资金资助项目(13061000485)
河北省卫生计生委科研基金资助项目(20120212)
关键词
胰高血糖素样肽-1
抑胃多肽
饱和脂肪酸
单不饱和脂肪酸
glucagon-like peptide-1
gastric inhibitory polypeptide
saturated fat acid
monounsaturated fat acid
