摘要
目的观察思美泰联合熊去氧胆酸治疗重度ICP的临床疗效。方法观察组孕妇给予思美泰1 000mg加入500ml 5%葡萄糖液中,静脉滴注,1次/d;熊去氧胆酸250mg,口服,4次/d,10d为1个疗程。对照组:熊去氧胆酸250mg,口服,4次/d,10d为1个疗程。结果观察组早产率、新生儿窒息、产后出血、新生儿体质量、羊水粪染、剖宫产率显著低于对照组(P<0.01)。治疗后观察组孕妇主要生化指标与治疗前比较均明显下降,差异有非常显著性(P<0.01),与对照组治疗后比较差异有统计学意义(P<0.05)。结论思美泰联合熊去氧胆酸(UDCA)治疗重度ICP孕妇,疗效满意。
Objective To observe the clinical efficacy for SAMe UDCA in the treatment of severe ICP.Methods The pregnant women in the observation group were given 1000mg SAMe mixed in 500ml glucose with the concentration of 5% by intravenous infusion once a day.And they were also given UDCA 250mg,they were oral,4 times a day,and 10 days were as a course of treatment.The control group： they were given UDCA 250mg,they were oral,4 times a day,and 10 days were as a course of treatment.Results The preterm birth rate,asphyxia,postpartum hemorrhage,neonatal weight,meconium-stained amniotic fluid,cesarean section rate for the observation group were significantly lower than the control group（P0.01）.The main biochemical indexes of pregnant women for the observation group decreased significantly after treatment than before treatment（P0.01）.There was statistically significant compared with the control group after treatment（P0.05）.Conclusions The efficacy for SAMe and UDCA in the treatment of of pregnant women with severe ICP is significant.
出处
《齐齐哈尔医学院学报》
2011年第22期3628-3628,3631,共2页
Journal of Qiqihar Medical University
