摘要
迟发型超敏反应即Ⅳ型变态反应，由抗原特异性T细胞介导，根据炎症因子和效应细胞的不同，迟发型超敏反应可分为Ⅳa～IVd四型。多数致敏药在人体内经代谢与蛋白结合后形成抗原，通过抗原提呈作用引起抗原特异性的皮肤固有T细胞及皮肤归巢T细胞活化，引发皮肤免疫反应。不同类型药疹的发生可涉及不同亚型的迟发型超敏反应以及不同的效应细胞与炎症因子。
Delayed-type hypersensitivity, also known as type IV allergic reaction, is mediated by antigen-specific T cells. It is subelassified into four subtypes, i.e., IVa to IVd, based on inflammatory eytokines and effeetors. Most sensitizing drugs must be metabolized or bioaetivated to a chemically reaetive form before they are able to eovalently bind to proteins and form antigens, which are subsequently presented to activate antigen-specific epidermal T cells and skin-homing T cells and to trigger a cutaneous immune response. Different types of cutaneous drug reactions are associated with different subtypes of delayed-type hypersensitivity as well as various effeetors and eytokines.
出处
《国际皮肤性病学杂志》
2012年第1期32-35,共4页
International Journal of Dermatology and Venereology
关键词
药疹
超敏反应
迟发型
Drug reactions
Hypersensitivity, delayed
