摘要
目的:观察醒脑静注射液联合依达拉奉治疗急性脑出血的临床疗效和安全性。方法:急性脑出血患者120例随机分为观察组和对照组。在常规对症治疗基础上,对照组予依达拉奉30 mg+0.9%氯化钠注射液100 ml,ivd,bid,观察组在对照组基础上再加用醒脑静注射液20 ml+5%葡萄糖注射液250 ml,ivd,qd。疗程均为2周。观察比较两组疗效、NIHSS评分、BI评分、C反应蛋白水平及药品不良反应。结果:观察组疗效明显优于对照组(70.00%vs 43.33%,P<0.05)。治疗后,两组NIHSS评分与C反应蛋白水平均较治疗前明显降低,而BI评分均较治疗前明显升高(P<0.05);且观察组与对照组NIHSS评分、BI评分和C反应蛋白水平比较,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(10.00%vs 3.33%,P>0.05)。结论:醒脑静注射液联合依达拉奉治疗急性脑出血,疗效确切,安全性佳,能有效恢复患者神经功能。
Objective： To observe the clinical effect and safety of Xingnaojing injection combined with edaravone in the treatment of acute cerebral hemorrhage. Methods： Totally 120 patients with acute cerebral hemorrhage from Janunary 2011 to Janunary 2013 were divided into two groups at random. On the basis of conventional symptomatic treatment, the control grouF was only with edaravone （30rag ＋ 100ml 0.9% sodium chloride injection）, ivd, bid, while the experiment group was treated with Xingnaojing injection （20ml ＋250ml 5% glucose injection） additionally, ivd, qd. The treatment course was two weeks. The clinical effect, NIHSS score, BI score, level of C reactive protein and untoward effect of the two groups were observed and compared. Results： The efficacy of the exper- iment group was obviously better than that of the control group（70.00% vs 43.33% ,P 〈 0.05 ）. The NIHSS score of the two groups after the treatment was both obviously lower than that before the treatment, and the BI score was obviously higher than that before the treatment. The difference in the NIHSS score and BI score before and after the treatment had statistical significance （ P 〈 0.05 ）. The reduction of C reactive protein in the experiment group was more obvious than that in the control group （ P 〈 0.05 ）, The difference in the untoward effect incidence between the two groups was without statistical significance （ 10.00% vs 3.33%, P 〉 0.05 ）. Conclu- sion： Patients with acute cerebral hemorrhage can be treated with Xingnaojing injection combined with edaravone effectively, which can recover the nerve function with good safety.
出处
《中国药师》
CAS
2015年第9期1533-1535,共3页
China Pharmacist
关键词
醒脑静注射液
依达拉奉
急性脑出血
Xingnaojing injection
Edaravone
Acute cerebral hemorrhage
