摘要
目的研究壮筋续骨汤促进大鼠股骨骨折愈合的作用。方法成年健康雄性Wistar大鼠50只,用线锯在股骨中段切断股骨制备骨折模型,应用壮筋续骨汤水煎液灌胃治疗。X线观察骨折愈合情况,苏木精-伊红染色观察骨折愈合的病理变化。结果治疗后7天,大鼠局部肿胀消失;X线片示纤维性骨痂开始形成,骨折线模糊;HE染色示骨折端断成纤维细胞和成骨细胞增多。治疗后14天,大鼠患肢活动逐渐恢复;X现示骨折处显示纤维性骨痂和钙盐沉积,骨折线消失;HE染色示骨折端有大量纤维性骨痂,软骨性骨痂和骨性骨痂,趋于愈合。结论壮筋续骨汤能促进实验性大鼠骨折愈合。
Objective To study the effect of ZhuangJinXuOuTang on enhancing the femoral fracture healing in experimental rats. Methods Total of 50 adult healthy male Wistar rats were established fracture models by cutting femur at middle point of rats, and treated with ZhuangJinXuGuTang. The fracture healing condition was observed by X-ray, and the pathological conditions of fracture healing were detected by HE staining. Results After treatment 7 days, the local swelling at femoral fracture subsided gradually. The fibrous callus tissue began forming to reduce the fracture line at X-ray film, and the fibroblast and osteoblast increased significantly at the fracture-end. At treatment 14 days, the movement of fractured limb recovered successfully, more fibrous callus tissue forming and calcium mineral deposited at the fracture-end to remove the fracture line at X-ray film, and more fibrous, cartilaginous and osseous callus tissues forming to enhance the fracture healing. Conclusion ZhuangJinXuGuTang could enhance the fracture healing in experimental facture rats.
出处
《临床医学工程》
2012年第1期26-27,31,共3页
Clinical Medicine & Engineering
基金
青岛大学优秀研究生学位论文培育项目(YSPY2011012)
关键词
壮筋续骨汤
骨折
X线
病理
大鼠
ZhuangJinXuGuTang
Fracture
X-ray
Pathology
Rats
