摘要
目的探讨反复上呼吸道感染(FURI)患者的细胞及体液免疫特征。方法收集现症及恢复期FURI患者各28例,选取健康体检者20例作为对照;用流式细胞术检测外周血CD4CD45RA及CD4CD45RO T细胞亚群的含量;运用速度散射比浊法测定IgG、IgA及IgM的含量;将T细胞亚群及Ig数量进行相关性分析。结果以上两组CD4CD45RA的变化趋势为现症组<恢复组<健康组(F=3.541,p=0.002),而CD4CD45RO为现症组>恢复组>健康组(F=3.612,p=0.001);IgG及IgA的变化趋势为:现症组<恢复组<健康组(F=3.023,p=0.012;F=2.862,p=0.018),IgM的组间变化趋势是:现症组>恢复组>健康组(F=2.592,p=0.026);相关性分析显示CD4CD45RA与CD4CD45RO呈显著负相关性,CD4CD45RO与IgM呈正相关性,CD4CD45RA与IgG及IgA均呈显著正相关性(均为p<0.05)。结论以CD4CD45RA/CD4CD45RO为代表的细胞免疫及以Ig为代表的体液免疫在URI发病及转归中发挥重要作用。
Objective To investigate the characteristics of cell immunity and humoral immunity in patients with frequent upper respiratory tract infection（FURI）. Methods 28 patients belonging to current acute infection,28 ones of convalescence and another 20 healthy people for routine examination were enrolled in our study（stated as group A,B and C）.The T cell subsets ratios of CD4CD45RA and CD4CD45RO were detected through flow cytometry.The quantity of IgG,IgA and IgM were determined by rate nephelometry.Pearson analysis was applied to analyze the correlation between T cell subsets and different immune globulins. Results The variation tendency of CD4CD45RA in the three groups was ABC（F=3.541,p=0.002）,whereas an opposite result was observed for CD4CD45RO： ABC（F=3.612,p=0.001）.The variation tendency of IgG and IgA was ABC（F=3.023,p=0.012;F=2.862,p=0.018 respectively） but that for IgM was ABC（F=2.592,p=0.026）.Pearson analysis showed there was a negative relation between CD4CD45RA and CD4CD45RO,and a positive relation was found between CD4CD45RO and IgM;furthermore,a positive correlation was also found between CD4CD45RA and IgG or IgA（all p0.05）. Conclusion Cell immunity of CD4CD45RA/CD4CD45RO and humoral immunity of immune globulins were both playing an important role in the development and turnover of FURI patients.
出处
《现代医院》
2011年第12期5-7,共3页
Modern Hospitals
关键词
上呼吸道感染
T细胞亚群
免疫球蛋白
免疫平衡
相关性分析
Upper respiratory tract infection
T cell subsets
Immune globulins
Immunologic balance
Correlation analysis
