摘要
目的研究微创埋线对咳嗽变异性哮喘患儿血清IgE、IgG、IgA及血小板活化因子(PAF)的影响。方法 2013年3月至2015年12月郑州市中医院、郑州市儿童医院、河南中医学院第三附属医院儿科门诊收治CVA患儿206例,随机分为观察组101例和对照组105例。观察组微创埋线联合口服孟鲁司特钠咀嚼片,对照组口服孟鲁司特钠咀嚼片。两组疗程均为3个月。观察治疗前后临床疗效及治疗前后血清IgE、IgG、IgA及PAF的变化。结果观察组总有效率为93.1%(94/101),对照组为87.6%(92/105),差异有统计学意义(P<0.05)。观察组治疗后血清总IgE、IgG、IgA、PAF水平的改善情况优于对照组,差异有统计学意义(P<0.05)。结论微创埋线可以提高IgA、IgG水平,提高患儿免疫力;可抑制PAF的过度释放控制炎症反应水平;可有效降低IgE介导的过敏反应,减少气道变态反应性炎症。
Objective To study the influence of minimally invasive embedded wire on serum IgE, IgG, IgA and PAF of children with cough variant asthma. Methods A total of 206 children with CVA who received treatment from Mar. 2013 to Dec. 2015 were randomly divided into observation group（101 children） and control group（105 children）. The observation group was treated with minimally invasive embedded wire and montelukast chewable tablets, while the control group only took montelukast chewable tablets. The treatment course was 3 months for both groups. Observe the clinical effect and the changes of IgE, IgG, IgA and PAF after treatment. Results The total effective rate of the observation group was 93.1~ （94/101） and it was 87.6 ~ （92/105） in the control group, the difference between them was of statistical significance （P〈0.05）. The improvement in serum level of total IgE, IgG, IgA and PAF was better in the observation group after treatment, and there was statistical difference（P〈0.05）. Conclusion Minimally invasive embedded wire can increase the level of IgA and IgG and the children＇s immunity. It can inhibit the excessive release of PAF and control inflammation level. It effectively reduce IgE-mediated allergic reaction and airway allergic inflammation.
出处
《中国中西医结合儿科学》
2017年第2期103-105,共3页
Chinese Pediatrics of Integrated Traditional and Western Medicine
基金
郑州市科技局2013年科技领军人才项目(131PLJRC672)
关键词
咳嗽变异性哮喘
微创埋线
儿童
Cough variant asthma
Minimally invasive embedded wire
Children
