摘要
目的对中药水蓼的化学成分进行研究。方法采用硅胶、凝胶柱色谱和重结晶等分离方法对体积分数为75%的水蓼全草乙醇溶液提取物进行成分分离,通过谱学分析方法结合理化性质进行结构鉴定。结果共分离得到10个化合物,分别鉴定为蒲公英萜酮(taraxerone,1)、木栓烷醇(friedelanol,2)、乌索酸(ursolic acid,3)、齐墩果酸(oleanolic acid,4)、3β,13β-二羟基-11-烯-28-乌索酸(3β,13β-dihydroxy-urs-11-en-28-oic acid,5)、没食子酸(gallic acid,6)、(-)-clovane-2,9-diol(7)、槲皮素(quercetin,8)、槲皮苷(quercitrin,9)、芦丁(rutin,10)。结论化合物5、7为从蓼属植物中首次分离得到,化合物1～4为从水蓼中首次分离得到。
Objective To study the chemical constituents from whole plant of Polygonum hydropiper L. Methods Compounds from 75 % ethanol extract of P. hydropiper L. were isolated by silica gel, Sephadex LH-20 column chromatographties, together with recrystallization method, and their structures were identified by means of NMR spectral analysis and the physico-chemical properties. Results Ten compounds were obtained and elucidated as taraxerone （ 1 ）, friedelanol （ 2 ）, ursolic acid （ 3 ） , oleanolic acid （ 4 ） , 3β, 13β-dihydroxy-urs-11 -en-28-oic acid （ 5 ）, gallic acid （ 6 ）, （ - ） -clovane-2,9-diol （ 7 ）, quercetin （ 8 ）, quercitrin （9）, rutin （10）, respectively. Conclusions Compounds 1-4 are isolated from this plant for the first time; compounds 5,7 are isolated from the Polygonum genus for the first time.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2012年第1期22-25,共4页
Journal of Shenyang Pharmaceutical University
关键词
水蓼
化学成分
结构鉴定
Polygonum hydropiper L.
chemical constituent
structure identification
