摘要
目的调查存在动脉粥样硬化危险因素人群中下肢动脉疾病(PAD)的发生率、共患率及治疗情况;评价踝臂指数(ABI)的临床应用价值及对心血管事件的预测价值。方法连续入选50岁以上伴多重危险因素的住院患者5 646例,测量ABI。进行PAD相关因素的多因素logistic回归分析。结果最终对5 263例患者进行分析。PAD总患病率为25.4%,女性患病率高于男性,PAD患者比非PAD患者年老,更多伴有糖尿病、冠心病、脑卒中、血脂紊乱和吸烟,PAD患者与非PAD患者的OR值证明这些因素与ABI相关。他汀类、血管紧张素转换酶抑制剂(ACEI)和抗血小板药物分别仅用于40.5%、53.6%、69.1%PAD患者。结论心血管高危患者中PAD患病率高,低ABI与全身性动脉粥样硬化具有相关性,ABI应成为心血管高危患者的常规检查,PAD患者需要得到强化治疗。
Objective To investigate the epidemiology, co-morbidities and risk factor pro- file of peripheral arterial disease （PAD） and evaluate the clinical significance of the ankle brachial in- dex （ABI） as an indicator of PAD in Chinese patients with high atherosclerosis risk. Methods ABI was measured in 5646 patients with high CV risk. Multivariable logistic regression analyses were performed to identify factors associated with PAD. Results A total of 5263 patients were analyzed. The prevalence of PAD in the total group of patients was 25.4 % and the prevalence was higher in females than in males. Patients with PAD were older than those without PAD, and more frequently had diabetes, coronary heart disease （CHD）, stroke, lipid disorders and a smoking habit. The ORs for the PAD group compared with the non- PAD group demonstrated that these conditions were in- versely related to ABI. Statin, angiotensin- converting enzyme- inhibitors and antiplatelet agents were only used in 40.5 %, 53.6 % and 69.1% of PAD patients respectively. Conclusion The data demonstrated the high prevalence and low treatment of PAD in Chinese patients with high CV risk. A lower ABI was associated with generalized atherosclerosis. Based on these findings, ABI should be used as a routine measurement in high - risk patients. Aggressive medication is required in these patients
出处
《实用临床医药杂志》
CAS
2011年第24期13-16,共4页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(41120009)
关键词
踝臂指数
动脉粥样硬化
下肢动脉疾病
ankle brachial index
atherosclerosis
peripheral arterial disease
