摘要
目的:探讨2种剂量来曲唑(LE)与克罗米芬(CC)对多囊卵巢综合征(PCOS)患者子宫卵巢血流动力学的影响。方法:2种剂量LE与CC治疗90例PCOS不孕症患者,随机分CC组(A组,n=32,50 mg/d)、低剂量LE组(B组,n=30,2.5 mg/d)和高剂量LE组(C组,n=28,5.0 mg/d)。同时以28例正常育龄妇女作为对照组(D组)。经阴道超声监测子宫卵巢血流的参数,比较排卵率、妊娠率。结果:①LE的2个剂量组子宫卵巢血流均出现类似正常育龄妇女的周期性血流变化;②C组方案治疗PCOS有较高的排卵率和妊娠率。结论:来曲唑改善了PCOS患者的子宫卵巢血流供应,5.0 mg可能有更好的促排卵效果。
Objective： To compare the effects of letrozole（LE） with two different doses and clomiphene citrate（CC） on uterine and ovarian blood flow in PCOS patients.Methods： Ninety consecutive patients of anovulatory PCOS were randomized into a 5.0 mg dose of CC（group A,n=32） or a 2.5 mg dose of LE（group B,n=30） or a 5.0 mg dose of LE（group C,n=28） daily for 5 d and compared with control group： normal women having spontaneous,ovulatory cycles（group D,n=28）.The peak systolic velocity（PSV）,end diastolic flow velocity（EDV）,spiral artery resistance index（RI） and pulsatility index（PI） of uterine and ovarian blood flow were assessed with transvaginal colour Doppler ultrasonography.Ovulation and pregnancy rate were calculated.Results： 1） In PCOS patients treated with two different doses of LE,the cyclic changes in uterine and ovarian blood flow are similar to those observed in healthy women.2） Both ovulation rate and pregnancy rate were significantly higher in patients receiving 5.0 mg LE compared with the other groups.Conclusion： Treatment with the aromatase inhibitor LE seems to improve uterine and ovarian blood flow in PCOS patients.Higher pregnancy rate was observed in patients received 5.0 mg letrozole.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2011年第12期838-842,852,共6页
Reproduction and Contraception
