摘要
目的:探讨氯米芬对多囊卵巢综合征患者卵巢血流的影响,为促进多囊卵巢综合征患者的康复提供科学依据。方法:选取2014年10月至2015年10月于我院就诊的多囊卵巢综合征不孕患者60例作为研究对象,随机分成对照组和观察组。观察组患者采用氯米芬治疗。监测两组对象的排卵情况及卵巢血流动力学参数、黄体生成素、血清睾酮、雌二醇水平和卵泡刺激素。结果:两组患者PI和RI均呈现周期性变化,且治疗后围排卵期、黄体中期PI、RI指标优于治疗前,差异有统计学意义(P<0.01)。观察组患者治疗后围排卵期、黄体中期PI、RI指标优于对照组,差异有统计学意义(P<0.01)。观察组排卵率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后FSH、LH、E2水平与治疗前相比均有改善,差异具有统计学意义(P<0.01)。观察组治疗后FSH、LH、E2水平优于对照组,差异具有统计学意义(P<0.01)。结论:氯米芬可在一定程度上改善多囊卵巢综合征患者的卵巢血流,但其虽排卵率高,妊娠率却不理想,尚需结合其他药物做进一步研究。
Objectives： To explore the effect of Clomiphene on ovary blood flow of patients with polycystic ovarian syndrome so as to provide scientific reference for the rehabilitation of patients with polycystic ovarian syndrome. Methods： 60 infertile patients with polycystic ovarian syndrome who had received treatment in the Gynecology Clinic of our hospital between October 2014 and October 2015 were taken as the research object,which were randomly divided into a control group and an observation group. Patients in the observation group were given Clomiphene for treatment. The ovulation,ovary haemodynamics index,luteinizing hormone,testosterone,level of estradiol and follicle- stimulating hormone of patients in the two groups were monitored. Results： PI and RI of patients in the two groups were changing periodically and after treatment,those in the ovulatory period and middle luteal phase were monitored to be better than those before the treatment,both the differences were statistically significant（ P〈0. 01）. Besides,the PI and RI in the ovulatory period and middle luteal phase in the observation group were shown to be better than those in the control group,and the difference was registered to be statistically significant（ P〈0. 01）. The ovulation rate in the observation group was shown to be higher than that in the control group,and the difference was statistically significant（ P 〈 0. 05）. After treatment,the FSH,LH and E2 levels were improved in both groups than before treatment,and the difference was registered to be statistically significant（ P〈0. 01）; those in the observation group were better than those in the control group,where the difference was statistically significant（ P〈0. 01）. Conclusion： Clomiphene can,to some extent,improve the ovarian blood flow in patients with polycystic ovary syndrome,which is with higher ovulation rate yet lower rate of pregnancy,so further studies concerning combined use of clomiphene and other medicines are needed.
作者
黎兴利
李维玲
张西艺
陈媛媛
LI Xingli LI Weiling ZHANG Xiyi CHEN Yuaayuan.(Department of Obstetrics, Xi＇ an Gaoxin Hospital, Xi＇ an 710075, Shaanxi, China)
出处
《中国性科学》
2017年第1期45-48,共4页
Chinese Journal of Human Sexuality
关键词
氯米芬
多囊卵巢综合征
血流动力学
血清睾酮
排卵
Clomiphene
Polycystic ovarian syndrome
Haemodynamics
Testosterone
Ovulation
