摘要
目的探讨丙帕他莫对开胸手术后患者自控镇痛(PCA)的影响。方法 120例拟行开胸手术并要求术后镇痛的患者随机分为I组(对照组)和II组(丙帕他莫组)。II组在术毕前30min给予丙帕他莫1g(生理盐水稀释为50ml)。I组给予等量生理盐水。PCA配方为舒芬太尼100μg+布托啡诺5mg+格拉斯琼10.5mg,负荷量为舒芬太尼5μg+格拉斯琼1.5 mg。置PCA泵后记录不同时间点疼痛VAS评分、镇静程度、各项生命体征;PCA按压次数、追加舒芬太尼剂量及副作用。结果 I组1、2hVAS评分、PCA总按压次数、追加药物显著高于II组(P<0.05)。两组其余时间VAS评分、镇静程度以及副作用发生率无显著性差异(P>0.05)。结论 PCA初期,丙帕他莫可减少开胸手术的患者术后镇痛药物的用量。
Objective To discuss the effect of propacetamol on patient-controlled analgesia（PCA） after thoracotomy.Methods 120 patients to receive thoracotomy were randomly divided into 2 groups： propacetamol group and control group;30 minutes before the operation ending,1g of propacetamol diluted in 50ml of NS was given to patients in propacetamol group while the same volume of NS was given to patients in control group;PCA was prepared with sufentanil 0.5μg/ml ＋ Butorphanol 0.5 mg ＋ granisetron 3mg,the load amount included sufentanil 5μg ＋ granisetron 1.5mg;after installation of PCA pump,the VAS scores,the depth of sedation,physical signs,the press times of PCA,the superaddition amount of sufentanil and the side effect were recorded at different time points.Results The VAS scores at the time point of 1 and 2 hours,the total press times of PCA and the superaddition amount in control group were much more than those in propacetamol group（P〈0.05）;there existed no obvious difference between the 2 groups in the VAS scores at other time points,the depth of sedation and the occurrence of side effect（P〈0.05）.Conclusions At the early stage of PCA,the application of propacetamol may decrease the amount of analgesic drugs in patients after thoracotomy.
出处
《西南军医》
2011年第6期996-998,共3页
Journal of Military Surgeon in Southwest China
关键词
全身麻醉
开胸手术
PCA
丙帕他莫
general anesthesia thoracotomy patient-controlled analgesia（PCA） propacetamol
