摘要
目的探讨老年髋部骨折患者术后采用舒芬太尼静脉镇痛的最小有效安全剂量。方法选择160例老年髋部骨折病人,随机分为四组,每组各40例。四组采用不同浓度舒芬太尼术后静脉镇痛:A组1.25μg/ml、B组1.0μg/ml、C组0.75μg/ml、D组0.50μg/ml。术后每隔6小时随访,利用视觉模拟评分法确定镇痛的效果同时观察镇静情况、药物消耗、恶心呕吐、瘙痒、呼吸抑制(呼吸<8次/min)等并发症发生。结果A、B、C组的各时段镇痛评分平均值都小于3分,镇痛效果满意,A组呼吸抑制、恶心呕吐在各时段的发生率高于其他三组,差异有统计学意义(χ2=4.02,P<0.05)。结论用于老年人髋部手术后静脉镇痛1.0μg/ml、0.75μg/ml浓度的舒芬太尼都是有效安全的浓度,0.75μg/ml可能是最佳有效浓度。
Objective To investigate the minimal effective concentrations of sulfentanyl in patient control intravenious analgesia in elders after hip operations. Methods 160 elder patients undergoing hip operations were randomly divided into four groups （n=40 each）. Different concentrations of sulfentanyl was used in each group. Group A received sulfentanyl 1.25μg/ml;Group B received sulfentanyl 1.0μg/ml ;Group C received sulfentanyl 0.75μg/ml;Group D received sulfentanyl 0.50μg/ml.Pain score, drug consumption, sedative score, blood pressure, respiratoy rate, SpO2 and heart rate were assessed at 0, 6, 12, 18, and 24 hrs after analgesia. Respiratory depression, nausea and vomiting, and pruritus were recorded. Results Both average VAS in group A, B, C〈3. Respiratory depression, nausea and vomiting in group A were significantly higher than in group B, C, D（χ^2=4.02, P〈0.05）. Conclusion concentrations of 1.0μg/ml or 0.75μg/ml sulfentanyl provide the optimum balance between pain relief and side effects after hip operations in elder patients and 0.75pμg/ml was the minimal effective concentration.
出处
《全科医学临床与教育》
2008年第2期104-107,共4页
Clinical Education of General Practice
基金
温州市医药卫生科研项目(2006A017)
关键词
舒芬太尼
老年人
镇痛病人自控
输注静脉
sulfentanyl
aged
patient-controlled analgesia
intravenous injection
