摘要
目的观察非甾体类抗炎药氟比洛芬与舒芬太尼合用于鼻内镜术后静脉自控镇痛的临床效果。方法拟行鼻内镜术后自控静脉镇痛64例,随机分为两组,实验组:舒芬太尼50μg,氟比洛芬300mg,恩丹西酮8mg,生理盐水稀释至100ml;对照组:舒芬太尼100μg,恩丹西酮8mg,生理盐水稀释至100ml。术毕使用患者自控静脉镇痛(patient controlled intravous analgesia,PCIA)负荷量5ml,持续给药速度1ml/小时,单次PCIA0.5ml,锁定时间15分钟。分别记录并比较术后各时间点患者疼痛视觉模拟(visual analog analgesia,VAS)评分、镇静评分及不良反应发生率。结果两组术后镇痛效果均满意,48小时内各时间点VAS评分无显著性差异(P<0.05)。实验组术后4、8、20小时3个时间点镇静评分小于对照组(P<0.05)。实验组不良反应少于对照组,其中头晕例数与对照组相比有显著性差异(P<0.05)。结论氟比洛芬复合舒芬太尼可有效用于鼻内镜术后静脉镇痛,明显减少舒芬太尼的剂量及不良反应,提高镇痛的安全性。
OBJECTIVE To evaluate the clinical effects of the mixture of flurbiprofen and sufentanil on PCIA for patients underwent FESS. METHODS Sixtyfour patients scheduled for PCIA after FESS were randomly divided into 2 groups： experimental group （n = 32, sufentanil 0.5 pg/mL plus flurbiprofen 3 mg/ml） and control group（n = 32, sufentanil 1 pg/ml）.PCIA was initiated after extubation with 5 ml bolus solution followed by constant infusion at rate of 1 ml/h. A dose of 0.5ml solution would be added when the pain was felt and the lockout time was 15 minutes. The differences of VAS, sedation score and occurrence of adverse effects were compared in the two groups at each time point. RESULTS There was no significant difference between the two groups in terms of VAS （P 〉0.05）. However, the sedation score of patients in the control group was significantly greater than that in the experimental group during the first 20 hours and more dizziness occurred in the control group （P〈0.05）. CONCLUSION The mixture of flurbiprofen and sufentanil is effective on PCIA for patients after FESS with less adverse effects and proved to be a safe adjuvant.
出处
《中国耳鼻咽喉头颈外科》
北大核心
2007年第12期711-713,共3页
Chinese Archives of Otolaryngology-Head and Neck Surgery
