摘要
目的:探讨口服N-乙酰半胱氨酸对噪声性聋的预防作用。方法:选择某部入伍1年以上健康军人363例作为受试者,随机分为实验组(223例)和对照组(140例),2组分别给予口服N-乙酰半胱氨酸和安慰剂,用法1 200mg/d×14d。2组受试者噪声暴露前、后均行纯音测听和ABR检查,对检查结果进行统计学分析。结果:2组受试者噪声暴露前后听力均有改变,组间差异有统计学意义。结论:口服N-乙酰半胱氨酸能有效减轻噪声暴露后噪声性聋的发生。
Objective：To evaluate the protective effects of oral administration of N-acetyl-cysteine（NAC） on noise-induced hearing loss.Method：Three hundred sixty three volunteers were recruited and randomly divided into two groups： experimental group（n=223） and control group（n=140）.The subjects had received oral administration of NAC in the experimental group and placebo in the control group before noise exposure.The routine audiometric evaluation and ABR testing were performed and recorded pre-and post-noise exposure.The statistical analysis was carried out on the data obtained from two groups with SPSS 11.0.Result：The hearings of all the participators were changed after noise exposure,but there were statistically significant differences between two groups.Conclusion：The protective effects of NAC were prominent on the noise-induced hearing loss.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2011年第22期1040-1041,共2页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
N-乙酰半胱氨酸
噪声性耳聋
听阈
N-acetyl-cysteine
noise-induced hearing loss
hearing threshold
