摘要
目的探讨N-乙酰半胱氨酸联合氢气在噪声性聋的预防作用及安全性。方法选择2017年5月-2018年2月长期处于噪声环境中的泸州市某化工厂人群500名作为入组对象,随机分为对照组(n=250)和观察组(n=250)。对照组给予N-乙酰半胱氨酸预防,观察组在对照组基础上联合氢气预防,14天干预后对两组效果进行评估,比较两组纯音测听、脑干诱发电位(ABR)检查结果、炎症因子及安全性。结果观察组经检查确定噪声性聋13例,占5.2%,低于对照组47例,占18.8%(P<0.05);2组干预前纯音测定及Ⅰ~Ⅴ波期间波Ⅴ阈值比较差异无统计学意义(P>0.05);观察组治疗后14天纯音测定水平高于对照组(P<0.05);观察组治疗后14天Ⅰ~Ⅴ波期间波Ⅴ阈值水平,低于对照组(P<0.05);观察组治疗后14天ENA-78、HMGB1水平均低于对照组(P<0.05);观察组与对照组治疗后耳鸣、失眠、头痛、恶心呕吐、皮疹发生率差异均无统计学意义(均P>0.05)。结论将N-乙酰半胱氨酸联合氢气用于噪声性聋中能获得良好的预防效果,有助于改善患者听力,降低炎症因子水平,安全性较高,值得推广应用。
Objective To investigate the preventive effect and safety of N-acetylcysteinecombined with hydrogen in noise enthalpy.Methods A total of 500 people in a chemical plant in Cangzhou City with long-term noise in May 2017-February 2018 were enrolled.The random number table was divided into control group(n =250) and observation group(n =250). The control group was given N-acetylcysteine prevention. The observation group was combined with hydrogen prevention on the basis of the control group. After14 days of intervention, the effects of the two groups were evaluated. The pure tone audiometry, ABR test results, inflammatory factors and safety were compared. Results The observation group was confirmed to have 13 cases of noise phlegm, accounting for 5.2%,which was lower than that of the control group(47 cases, accounting for 18.8%(P<0.05). There was no statistical difference between the two groups before the intervention, the pure tone measurement and the Ⅳ wave period Ⅴ threshold. The significance of learning(P>0.05);the level of pure tone measured in the observation group was higher than that in the control group at 14 days after treatment(P<0.05);the threshold value of wave Ⅴ during the observation period was 14 days after treatment, which was lower than that of the control group(P<0.05). The levels of ENA-78 and HMGB1 in the observation group were lower than those in the control group at 14 days after treatmen t(P<0.05). There was no significant difference in the incidence of tinnitus,insomnia, headache, nausea and vomiting and rash after treatment between the observation group and the control group(P>0.05).Conclusion N-acetylcysteine combined with hydrogen can achieve good preventive effect in noise sputum, which can improve the hearing of patients and reduce the level of inflammatory factors. It is safe and worthy of popularization and application.
作者
周艳
ZHOU Yan(Monitoring section of Luzhou Center for Disease Control and Prevention,Luzhou Sichuan,646000,China)
出处
《职业与健康》
CAS
2019年第15期2037-2039,共3页
Occupation and Health
