摘要
目的探讨米非司酮联合氨甲喋呤治疗输卵管妊娠的临床效果。方法对110例未破裂型输卵管妊娠患者按入院先后随机分为观察组及对照组(每组均55例),观察组给予MTX加米非司酮治疗,对照组给予MTX加安慰剂治疗。对两组之间的平均住院时间、血β-hCG降至正常时间和异位妊娠包块直径缩小及成功率、不良反应等临床指标进行比较。结果治疗的成功率、平均住院时间、血β-hCG降至正常时间和异位妊娠包块直径缩小率,两组之间的差异具有显著性(P<0.05);不良反应两组间差异无显著性(P>0.05)。结论米非司酮联合氨甲喋呤可提高治疗非破裂型输卵管妊娠成功率而不增加不良反应,优于单用氨甲喋呤,值得临床推广应用。
Objective To explore the clinical effect of mifepristone combined with Methotrexate in the treatment for unruptured tubal pregnancy.Methods By order of admission,110 patients with unruptured tubal pregnancy were randomly divided into observation group and control group（n=55）.Observation group was given MTX plus mifepristone treatment,control group was given MTX plus placebo.The clinical parameters between the two groups were compared including the average length of stay,serum β-HCG dropped to normal time and the ectopic pregnancy mass diameter narrowing and the success rate,etc.Results Treatment success rate,average length of stay,serum β-HCG dropped to normal time and reduce the rate of ectopic pregnancy mass diameter,etc.The difference between the two groups was significant（P0.05）;adverse reactions had no difference between the two groups significantly（P0.05）.Conclusions Methotrexate combined with mifepristone can improve the success rate in treatment of unruptured tubal pregnancy without increasing adverse events than methotrexate alone,is worthy of clinical application.
出处
《齐齐哈尔医学院学报》
2011年第18期2929-2930,共2页
Journal of Qiqihar Medical University
