摘要
目的:探讨新疆地区三阴性乳腺癌与非三阴性乳腺癌患者临床特征及预后。方法:选取2002年1月至2003年12月本院收治的可手术切除并经病理证实的333例乳腺癌患者,依据ER、PR、Her-2的表达状况将其分为两组,三者表达均为阴性即为三阴性乳腺癌,另一组即为非三阴性乳腺癌,比较两组临床特征、复发转移情况及5年无瘤生存率。结果:333例乳腺癌患者中,三阴性乳腺癌82例,占24.62%,其淋巴结阳性率为41.5%,截止至随访日期,82例三阴性乳腺癌复发转移21例(25.61%),251例非三阴乳腺癌复发转移38例(15.14%),与非三阴性乳腺癌相比,其远处转移的危险比为2.041(P=0.015),肺转移的危险比为2.551(P=0.036),手术后3年内复发转移风险危险比为1.948(P=0.042),生存分析显示三阴性乳腺癌5年无瘤生存率为74.4%,非三阴性乳腺癌为84.9%,两组曲线比较P=0.027。结论:三阴性乳腺癌淋巴结阳性率较非三阴乳腺癌高,其复发转移风险高于非三阴组,主要是远处转移风险较高,具体表现为肺转移风险高于非三阴组,并在术后的3年内复发转移风险高,且5年无瘤生存率低于非三阴性乳腺癌,临床预后差。
Objective： To analyze the clinicopathologic features and prognosis of triple-negative breast cancer （ TNBC ）. Methods： Clinical data from 333 operable patients that were histopathologically confirmed in the Xinjiang Cancer Hospital from January 2002 to December 2003 were analyzed. The patients were divided into two groups according to the results of immunohistochemical staining. One group was the triple negative breast cancer （ TNBC ）, which included estrogen receptor （ ER ） negative, progesterone receptor （ PR ） negative, and human epidermal growth factor receptor （ HER2 ） negative, and the other was the non-triple-negative breast cancer group. The clinicopathologic features, local recurrence and metastasis, and 5-year disease-free rates were compared between the two groups. Results： Of the 333 patients, 82 （ 24.62% ） were confirmed as triple-negative breast cancer. The lymph node positive rate in the triple negative breast cancer patients was 41.5%. During follow-up, 21 cases （ 25.61% ） had local recurrence and metastasis occurred in 82 triple-negative breast cancer patients, whereas 38 cases （ 15.14% ） had local recurrence and metastasis among the 251 non-triple-negative breast cancer patients. Compared with the non-triple-negative breast cancer group, the hazard rate of distant metastasis in triple negative breast cancer group was 2.041 （ P = 0.015 ）, the hazard rate of lung metastasis was 2.551 （ P = 0.036 ）. The hazard rate of recurrence and metastatic risk within 3 years after the operation was 1.948 （ P = 0.042 ）. Survival analysis showed that 5-year disease-free rates of triple negative breast cancer and non-triple-negative breast cancer were 74.4% and 84.9%, respectively. The comparison of two curves in the two groups： Log rank - 4.904, P = 0.027. Conclusion： The positive rate of the lymph nodes was higher in the triple-negative breast cancer. The risk of local recurrence and metastasis is higher in the triple-negative groups, which mainly mani- fest
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2011年第18期1159-1162,共4页
Chinese Journal of Clinical Oncology
关键词
三阴性乳腺癌
临床特征
预后
Triple-negative breast cancer
Clinical characteristics
Prognosis
