摘要
目的:探讨Ⅰ_A期乳腺癌患者的临床病理特征与预后因素。方法:回顾性分析2004年1月—2009年12月天津医科大学肿瘤医院收治的156例IA期(T1N0M0,)乳腺癌患者的临床病理资料。结果:156例患者均为女性;病理类型以浸润性导管癌为主(115例,73.7%);原发肿瘤大小以T1c居多(77例,49.4%);组织学分级以II级(79例,50.6%)及III级(58例,37.2%)为主。5年无进展生存(PFS)为93.3%,5年总生存(OS)为99.1%。单因素分析结果显示,组织学分级、Ki-67表达及淋巴脉管侵犯与患者的PFS有关(均P<0.05);多因素分析显示,组织学分级及Ki-67表达情况是影响患者PFS的独立预后因素(均P<0.05)。结论:IA期乳腺癌患者虽然总体预后较好,但对于某些亚组患者而言,预后较差,该类患者的复发转移风险较大。
Objective： To investigate the clinicopathologic characteristics and prognostic factors of patients with stage IA breast cancer. Methods： The clinicopathologic data of 156 patients with IA stage （T1N0M0） breast cancer treated in Cancer Hospital of Tianjin Medical University from January 2004 to December 2009were retrospectively analyzed. Results： Of the 156 patients, all cases were female; inifltrate ductal carcinoma accounted for the majority of the pathological types （115 cases, 73.7%）, the primary tumor sizes were mostly classiifed as T1c （77 cases, 49.4%）and histological grades were mainly grade II （79 cases, 50.6%） and III （58 cases, 37.2%）. hTe 5-year progress-free survival （PFS） was 93.3% and overall survival （OS） was 99.1%, respectively. Univariate analysis showed that histological grade, Ki-67 expression and lymphvascular invasion were significantly related to the PFS of the patients （allP〈0.05）. Multivariate analysis identified that histological grade and Ki-67 expression were independent prognostic factors for PFS of the patients （bothP〈0.05）. Conclusion： Although the overall prognosis of stage IA breast cancer patients is favorable, patients in some subgroups still have great risk of recurrence and metastases, and they have a poor prognosis.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2016年第8期1193-1197,共5页
China Journal of General Surgery
基金
国家科技支撑计划资助项目(2005BAI12B15)
关键词
乳腺肿瘤
无病生存
危险因素
Breast Neoplasms
Disease-Free Survival
Risk Factors
