摘要
目的分析甲状腺癌组织中p53、ki-67蛋白表达与其临床病理的关系。方法从我院择取80例甲状腺癌患者,对所选患者甲状腺癌组织中p53、ki-67蛋白表达进行检测,对检测结果进行分析,并分析其与临床病理之间的关系。结果从组织学类型来看,56例乳头状癌患者中,p53表达阳性24例,ki-67蛋白表达为(3.90±1.43)%,18例滤泡性癌患者中,p53表达阳性12例,ki-67蛋白表达为(6.72±1.25)%,4例髓样癌患者中,p53表达阳性3例,ki-67蛋白表达为(20.82±4.26)%,2例未分化癌患者中,p53表达阳性2例,ki-67蛋白表达为(31.16±3.43)%。未分化癌患者p53阳性表达率高于其他类型,同时ki-67蛋白表达也高于其他类型,P<0.05。结论对于甲状腺癌患者来说,甲状腺癌组织中p53、ki-67蛋白表达不仅与病灶浸润程度有关,而且与淋巴结转移有关,这两项指标联合检测可以早期诊断甲状腺癌,同时对患者预后有判断作用,可以为临床治疗方案的制定提供支持。
Objective to analyze relationship between p53 and ki-67 protein expression in thyroid cancer and its clinicopathology.Methods choose 80 cases thyroid cancer patients in our hospital.Detect expressions of p53 and ki-67 protein in thyroid cancer tissues,and analyze relationship between them and clinicopathology.Results based on perspective of histological type,among 56 cases papillary carcinoma patients,24 had positive expression of p53,and expression of ki-67 protein was(3.90±1.43)%.Among 18 follicular cancer cases,12 had positive expression of p53,Ki-67 protein expression was(6.72±1.25)%,among 4 cases medullary carcinoma patients,3 cases had positive expression of p53,ki-67 protein expression was(20.82±4.26)%,for 2 cases undifferentiated cancer,2 cases had positive expression of p53,expression of ki-67 protein was(31.16±3.43)%.Positive expression rate of p53 among undifferentiated cancer patients was higher than other types,and expression of ki-67 protein was higher than other types,P<0.05.Conclusion expression of p53 and ki-67 protein in thyroid cancer tissues of thyroid cancer patients is related to lesion invasion degree,and to lymph node metastasis.Combined detection of two indicators can diagnose thyroid cancer early with estimation of prognosis,which can provide support for formulation of clinical treatment plans.at the same time.
作者
黄金宁
HUANG Jin-ning(Maoming City Dianbai District People's Hospital,Maoming,Guangdong 525400)
出处
《智慧健康》
2020年第18期10-11,共2页
Smart Healthcare
