摘要
目的掌握新生儿重症监护病房(NICU)患儿细菌定植状况及与医院感染关系,为NICU医院感染预防控制提供证据。方法对照组患儿698例,观察组患儿966例;观察组所有患儿在入院时常规进行痰或咽拭子培养,查定植菌和药物敏感试验;比较两组患儿感染率、感染暴发次数、呼吸机相关性肺炎(VAP)发生率。结果对照组698例患儿中,73例发生医院感染,感染率为10.46%,观察组966例患儿中,58例发生医院感染,感染率为6.00%(P<0.05);对照组、观察组VAP发生率分别为2.29%、0.62%(P<0.01),感染暴发分别为2、0次;观察组送检痰和咽拭子标本966份,703份有细菌定植,定植率为72.77%,检出致病定植菌432份,检出率为61.45%;432例致病菌定植患儿发生医院感染51例,感染率11.81%,占总感染例数的87.93%;无致病菌定植患儿发生医院感染7例,感染率1.31%,占总感染例数的12.07%,差异有统计学意义(χ2=37.76,P<0.01);432株致病定植菌中,革兰阴性杆菌282株,占65.28%,革兰阳性球菌占34.72%。结论定植菌筛查可早期评估新生儿感染风险,实现医院感染防控早发现、早诊断、早治疗、早防护原则。
OBJECTIVE To master bacteria colonization condition of neonatal intensive care unit（NICU）and provide evidence for hospital infection prevention and control of NICU.METHODS A total of 698 cases in the control group,966 cases in the observation group.sputum culture and throat swab culture had been done when all the neonatal entered the hospital to check colonization bacteria and the drug sensitivity test was made.The hospital infection rate,the infection outbreak times,the VAP originating rate between these two groups were compared.RESULTS The hospital infection rate of the control group was 10.43% and the observation group was 6.00%（P〈0.05）.The incidence of VAP rate of the control group was 2.29% and the observation group was 0.62%（P〈0.05）.The infection outbreak times of the control group was 2 and the observation group was 0.In the 966 samples of the observation group,the bacteria colonization rate was 72.77% and the pathogenic bacteria was 61.45%.The hospital infection rate of pathogenic bacteria colonization patients were 11.81% and non-pathogenic bacteria colonization patients were 1.31%（P〈0.01）.In the colonization bacteria,the Gram-negative bacillus was 65.28% and the Gram-positive bacillus was 34.72%.CONCLUSION Colonization bacteria screening can evaluate the infection risk of neonatal early and prevent NICU hospital infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第20期4237-4239,共3页
Chinese Journal of Nosocomiology
关键词
新生儿重症监护病房
医院感染
定植菌
Neonatal intensive care unit
Hospital infection
Colonization bacteria
