摘要
目的分析婴幼儿多重耐药菌(MDRO)的感染特征,为制定医院感染预防控制措施提供科学依据。方法运用快速显色培养基对入院48小时内的危重转运患儿的鼻咽拭子、肛拭子标本进行甲氧西林耐药金黄色葡萄球菌(MRSA)和产超广谱β-内酰胺酶(ESBL)的肠杆菌的主动筛查,分析比较不同性别、年龄、是否接受侵入性操作、早产儿及住院时间长短的研究对象MRSA、产ESBLs杆菌检测阳性率,描述婴幼儿多重耐药菌的感染特征。结果本研究对1 013例患儿进行MRSA、ESBLs的主动筛查,阳性率分别为6.5%、43.3%,男、女之间阳性率差异无统计学意义(p>0.05)。年龄1～2个月及6个月以上患儿的ESBLs检出阳性率(≥60.0%)较高(p=0.001),2～6个月的患儿MRSA的筛查阳性率(20.6%)高于其他年龄组的患儿(p=0.032)。早产儿、接受侵入性操作及住院时间越长的患儿的多重耐药菌的定植率越高(p>0.05)。结论婴幼儿多重耐药菌的定植或感染可能受年龄、侵袭性操作、早产儿、住院时间影响,而与性别无关,早期发现可避免多重耐药菌的扩散传播。
Objective To describe and analyze the epidemiology characterization of multi resistant organism （ ESBLs - producing enterobacteria and methicillin - resistant Staphylococcus aureus MRSA） among young children, and provide scientific evidence for nosoeomial infection control. Methods Nasal and anus swab of young children were collected in 48 hours after their admission to the hospital, the clinical microbiology laboratory processed the swabs with selective chromogenic agar the isolation of ESBLs and MRSA. General information of all participates were obtained by consulting their medical records and other hospital records. Then MDRO epidemiology of young children was analyzed by comparing the ESBLs and MRSA positive rate of different gender, age, hospitalization stay, be pre- mature infants and with invasive operation or not. Results 1 013 young children participated in the study for ESBLs and MRSA active surveillance culture, and the positive rate were 43.3% ,6.5% respectively. MDRO positive rate of male and female were similar （p 〉 0.05 ）. The colonization rate of ESBLs of children aged 1 - 2month and over 6 month was higher than else （p =0. 001 ）, and 2 -6month old children for MRSA （p =0. 032）. ESBLs and MRSA colonization was positively associated with hospitalization stay, premature infants and invasive operation （p 〈0. 05 ）. Conclusion The colonization of MDRO among young children was related to age, hospitalization stay, premature in- fants and invasive operation, and not to gender. Actively screening would beneficial to detect the status of colonization of MDRO and prevent the transmission.
出处
《现代医院》
2013年第7期65-67,共3页
Modern Hospitals
关键词
婴幼儿
多重耐药菌
主动筛查
流行特征
Young children, Multi resistant organism, Active surveillance culture, Epidemiology
