摘要
目的总结探讨儿童双侧肾母细胞瘤综合治疗的疗效及随访结果。方法回顾性分析我院自1998年8月至2010年8月手术治疗的双侧肾母细胞瘤患儿临床资料。结果7例双侧肾母细胞瘤中，男性患儿3例，女性患儿4例，发病年龄最大21个月，最小6个月，平均年龄（12．71±4．89）个月。临床表现腹部肿块7例（7／7），血尿1例（1／6），贫血2例（2／6），4（4／7）例活检明确病理经术前化疗后手术，3例先手术后化疗，1例化疗2个疗程疾病进展，家属放弃治疗后死亡，5例结束整个疗程随访中，4例带瘤生存，1例随访7个月后残余肿瘤病灶消失，随访时间最长10年，最短10个月，1例术后化疗中，2年存活率85．7％。结论儿童双侧肾母细胞瘤通过手术、化疗及放疗综合治疗，可以带瘤生存。
Objective To retrospective analysis of the results of surgery management for children with bilateral wilms＇ tumor. Methods Seven patients with bilateral wilms＇ tumor were enrolled and follow-up from oct. 1998 to oct. 2010. Results The relevant data were collected. There were 3 males and 4 females, The maximal age at diagnosis was 21 months, minimal age was 6 months, average age was 12. 71 ± 4. 89 months. Clinical symptom included abdominal mass （7/7）, hematuria （1/6） and anemia （2/6）. Four cases underwent operation after preoperative chemotherapy, 3 cases were give adjuvant chemotherapy after operation, 5 cases completed chemotherapy, 1 case died during chemotheraphy. Five cases were followed up, 4 lived with tumor bearing, 1 residual tumor disappeared, The maximal follow-up time was 10 year, minimal follow-up time was 10 months. Two years survival rate was 85.7%. Conehtsions The patients with bilateral wilms＇ tumor can live with tumor bearing after standardized multidisciplinary treatment.
出处
《中华小儿外科杂志》
CSCD
北大核心
2011年第9期655-657,共3页
Chinese Journal of Pediatric Surgery
关键词
肾母细胞瘤
综合疗法
外科手术
Nephroblastoma
Combined modality therapy
Surgical procedures, operative
