摘要
缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD)是围产期常见疾病,致病机制尚未完全明确,治疗困难,预后差。少突胶质前体细胞(Oligodendrocyte precursor cell,OPC)是HIBD的主要靶细胞之一。缺氧缺血可以通过凋亡、氧自由基、兴奋毒性损伤等途径引发OPC死亡。亚低温、神经营养因子、OPC移植等方法可以通过抑制凋亡、抗氧化应激、拮抗兴奋毒性损伤等机制用于临床治疗HIBD。
Hypoxic-ischemic brain damage is a common disease in perinatal period,and it′s pathogenic mechanism is not definite completly.It is difficult to treat HIBD and the prognosis is not ideal.Oligodendrocyte precursor cell is the main target of HIBD.Hypoxic-ischemia can induce OPC to die through apoptosis,oxygen radicals and exitotoxicity.Mild hypothermia,neurotrophic factors and OPC transplantation can be applied to treat HIBD through depressing apoptosis,confronting oxygen radicals and inhibitting exitotoxicity.
出处
《中国优生与遗传杂志》
2011年第10期7-9,共3页
Chinese Journal of Birth Health & Heredity
