摘要
目的探讨新生儿接种血源性乙型肝炎(乙肝)疫苗(Blood-borne Hepatitis B Vaccin,HepB-B)后的长期免疫效果。方法对1986年出生并接种HepB-B的对象隔年随访1次,考核HepB-B接种率、及时接种率,采血检测乙肝病毒表面抗原(Hepatitis B Virus Surface Antigen,HBsAg)、抗乙肝病毒表面抗原抗体(Antibody to HBsAg,Anti-HBs)、抗乙肝病毒核心抗原抗体;1998年以后对HepB-B免疫人群开展乙肝发病监测。结果 HepB-B接种率、及时接种率持续稳定在98%左右。20年间12次随访检测HBsAg阳性率始终<1%,20年平均HBsAg阳性率0.61%,较免疫前本底同年龄组HBsAg阳性率下降93.59%。免疫后20年HBsAg阳性率为0.54%,低于20年平均HBsAg阳性率(0.61%),显示HepB-B远期保护效果良好。1986年后出生并已接种HepB-B的对象中,仅2002年和2007年各报告1例乙肝。结论新生儿HepB-B免疫后20年尚无需加强免疫。
Objective To investigate the long term immune protective effect of blood-borne hepatitis B vaccine for the newborns.Methods Newborns were subjected fellow-up observation every 2 years after vaccination since 1986.The coverage rate and timely coverage rate were collected.Blood samples were detected hepatitis B virus（HBV）surface antigen（HBsAg）,antibody to HBsAg（Anti-HBs）,and antibody to HBV core antigen.Hepatitis B incidence surveillance observation was carried out from 1998.Results Coverage rate,timely coverage rate were about 98%.During the past 20 years,12 time fellow-up observations were carried out,and the HBsAg positive rate was 1%.The average positive rate was 0.61%,which is 93.5% lower than the control population.Only 2 cases of hepatitis B positive were reported among the people with vaccination.Conclusion It is not necessary for the newborns to have the booster of hepatitis B vaccination 20 years after the primary immunization.
出处
《中国疫苗和免疫》
CAS
2011年第4期291-293,298,共4页
Chinese Journal of Vaccines and Immunization
关键词
血源性乙型肝炎疫苗
预防接种管理
发病监测
随访研究
Blood-borne hepatitis B vaccine
Vaccination management
Incidence surveillance
Fellow up research
